||Recombinant Human SGSH (1 a.a. - 502 a.a.) fused with GST-tag at N-terminal, was expressed in vitro wheat germ expression system.
||This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.
||50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
||Store at -80°C. Aliquot to avoid repeated freezing and thawing.