"TDO2" Related Products


Recombinant Human TDO2 protein, His-tagged

Cat.No.: TDO2-724H
Product Overview: Recombinant Human TDO2(2-406 aa) fused with His tag at N-terminal was expressed in E. coli.
Description: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Source: E. coli
Species: Human
Tag : His
Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween 20, 20% glycerol, 440 mM Imidazole
Molecular Mass: 49 kDa
Purity: >92%
Applications: Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors.
Storage: At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Concentration: 0.65 mg/ml
Gene Name: TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens ]
Official Symbol: TDO2
Synonyms: TDO2; tryptophan 2,3-dioxygenase; TDO; TPH2; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase; TO; TRPO;
Gene ID: 6999
mRNA Refseq: NM_005651
Protein Refseq: NP_005642
MIM: 191070
UniProt ID: P48775
Chromosome Location: 4q31-q32
Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Monoamine Transport, organism-specific biosystem; NAD biosynthesis II (from tryptophan), organism-specific biosystem; NAD biosynthesis II (from tryptophan), conserved biosystem; Tryptophan catabolism, organism-specific biosystem;
Function: amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; tryptophan 2,3-dioxygenase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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