"AHSG" Related Products

Expand
Expand

Recombinant Human Alpha-2-HS-Glycoprotein

Cat. No. : AHSG-4356H
Product Overview : The human Alpha-2-HS-Glycoprotein was purified from the human plasma.
Description : Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains. Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation. Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.
Source : Human
Host : Purified from the human plasma.
Form : Filtered (0.4µm) and lyophilized from 0.5 mg/ml in PBS pH 7.4.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Physical Appearance : Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Storage : Store the lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C.
Functions : cysteine-type endopeptidase inhibitor activity; kinase inhibitor activity; protein binding
Gene Name : AHSG alpha-2-HS-glycoprotein [ Homo sapiens ]
Official Symbol : AHSG
Synonyms : AHSG; alpha-2-HS-glycoprotein; AHS; A2HS; HSGA; FETUA; fetuin-A; Ba-alpha-2-glycoprotein; Alpha-2-Z-globulin; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; PRO2743
Gene ID : 197
mRNA Refseq : NM_001622
Protein Refseq : NP_001613
MIM : 138680
UniProt ID : P02765
Chromosome Location : 3q27.3

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.