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Recombinant Human Alpha-2-HS-Glycoprotein

Cat.No. : AHSG-4356H
Product Overview : The human Alpha-2-HS-Glycoprotein was purified from the human plasma.
  • Specification
  • Gene Information
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Cat. No. : AHSG-4356H
Description : Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains. Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation. Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.
Source : Human
Host : Purified from the human plasma.
Form : Filtered (0.4µm) and lyophilized from 0.5 mg/ml in PBS pH 7.4.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Physical Appearance : Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Storage : Store the lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C.
Functions : cysteine-type endopeptidase inhibitor activity; kinase inhibitor activity; protein binding
Gene Name : AHSG alpha-2-HS-glycoprotein [ Homo sapiens ]
Official Symbol : AHSG
Synonyms : AHSG; alpha-2-HS-glycoprotein; AHS; A2HS; HSGA; FETUA; fetuin-A; Ba-alpha-2-glycoprotein; Alpha-2-Z-globulin; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; PRO2743
Gene ID : 197
mRNA Refseq : NM_001622
Protein Refseq : NP_001613
MIM : 138680
UniProt ID : P02765
Chromosome Location : 3q27.3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How can proteomics approaches be used to study the protein-protein interactions involving AHSG in a global context? 08/14/2022

Techniques like co-immunoprecipitation coupled with mass spectrometry can reveal AHSG's interactome, shedding light on its broader functional networks.

Explain the potential diagnostic applications of AHSG in conditions such as chronic kidney disease and diabetes? 07/09/2022

AHSG levels may be altered in these conditions, making it a potential biomarker for disease progression or severity.

Explain the potential role of AHSG in mediating endocrine functions and its connection to insulin resistance? 12/31/2021

AHSG's interaction with insulin and adipokines could impact insulin sensitivity and metabolism, contributing to insulin resistance in conditions like type 2 diabetes.

Discuss the interactions between AHSG and other proteins, particularly its relationship with fetuin-B and fetuin-A? 06/11/2021

AHSG can form complexes with fetuin-B and fetuin-A, which have implications for calcium homeostasis, insulin signaling, and other physiological processes.

Explain AHSG's role in modulating immune responses and its potential relevance to autoimmune disorders? 08/02/2020

AHSG can interact with immune cells and cytokines, potentially influencing immune responses. Dysregulated AHSG levels might contribute to autoimmune diseases.

How might AHSG's interactions with circulating proteins influence its functions and its potential clinical relevance? 02/19/2020

AHSG's interactions with proteins like albumin and hormones can impact its bioavailability and activity, influencing physiological processes.

Describe the biochemical methods used to analyze AHSG's post-translational modifications, including glycosylation. 06/13/2019

Techniques such as mass spectrometry, lectin affinity chromatography, and glycan analysis can provide insights into AHSG's glycosylation patterns.

How does AHSG regulate calcium homeostasis, and what implications does this have for human health? 03/22/2019

AHSG binds to calcium ions and influences their distribution in the body. Dysregulation may impact bone health and contribute to conditions like osteoporosis.

How can researchers isolate and purify AHSG for biochemical studies in the laboratory? 10/28/2018

Techniques such as ion exchange chromatography, gel filtration, and affinity chromatography can be used to isolate and purify AHSG from biological samples.

How might genetic variations in the AHSG gene impact its protein expression and functions? 05/04/2018

Genetic polymorphisms in the AHSG gene might lead to altered AHSG levels or structural changes, potentially influencing its physiological roles.

Customer Reviews (5)

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Reviews
06/03/2022

    Absolutely loving the lab protein – a real game changer!

    10/19/2021

      Great value for the quality, and the speedy delivery was a pleasant surprise!

      08/16/2020

        Thumbs up for the protein, it's become my new favorite.

        02/27/2019

          Can't help but smile at the results from the product!

          12/11/2018

            Balanced pricing, superior quality, and top-level customer assistance.

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