"CASQ2" Related Products

Expand
Expand
Expand

Recombinant Human Calsequestrin 2 (Cardiac Muscle), His-tagged

Cat. No.: CASQ2-4248H
Product Overview: CASQ2 Human Recombinant fused to 37 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 417 amino acids (20-399 a.a.) and having a molecular mass of 48.4 kDa. The CASQ2 is purified by proprietary chromatographic techniques.
Description: CASQ2 belongs to the calsequestrin family and is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. CASQ2 is a calcium binding protein that stores calcium for muscle function. The discharge of calcium bound to CASQ2 through a calcium release channel activates muscle contraction. CASQ2 binds 40 to 50 moles of calcium. CASQ2 mutations result in stress-induced polymorphic ventricular tachycardia, also called catecholaminergic polymorphic ventricular tachycardia 2 which is known fir its bidirectional ventricular tachycardia that causes cardiac arrest.
Source: Human
Host: Escherichia Coli.
Form: The CASQ2 solution contains 20mM Tris-HCl pH-8, 0.1M NaCl, 1mM DTT and 20% glycerol.
Purity: Greater than 95% as determined by SDS-PAGE.
Physical Appearance: Sterile Filtered clear colorless solution.
Amino acid sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEEG LNFPTYDGKD RVVSLSEKNF KQVLKKYDLL CLYYHEPVSS DKVTQKQFQL KEIVLELVAQ VLEHKAIGFV MVDAKKEAKL AKKLGFDEEG SLYILKGDRT IEFDGEFAAD VLVEFLLDLI EDPVEIISSK LEVQAFERIE DYIKLIGFFK SEDSEYYKAF EEAAEHFQPY IKFFATFDKG VAKKLSLKMN EVDFYEPFMD EPIAIPNKPY TEEELVEFVK EHQRPTLRRL RPEEMFETWE DDLNGIHIVA FAEKSDPDGY EFLEILKQVA RDNTDNPDLS ILWIDPDDFP LLVAYWEKTF KIDLFRPQIG VVNVTDADSV WMEIPDDDDL PTAEELEDWI EDVLSGKINT EDDDEDDDDD DNSDEEDNDD SDDDDDE.
Storage: CASQ2 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
Gene Name: CASQ2 calsequestrin 2 (cardiac muscle) [ Homo sapiens ]
Official Symbol: CASQ2
Synonyms: CASQ2; calsequestrin 2 (cardiac muscle); PDIB2; FLJ26321; FLJ93514; calsequestrin-2; OTTHUMP00000013749; calsequestrin, cardiac muscle isoform; calsequestrin 2, fast-twitch, cardiac muscle; Calsequestrin-2
Gene ID: 845
mRNA Refseq: NM_001232
Protein Refseq: NP_001223
MIM: 114251
UniProt ID: O14958
Chromosome Location: 1p13.3-p11
Pathway: Calcium Regulation in the Cardiac Cell
Function: calcium ion binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.