"CCL2" Related Products

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Recombinant Human Chemokine (C-C Motif) Ligand 2

Cat. No.: CCL2-281H
Product Overview: Recombinant Human MCP-1 also known as Monocyte Chemotactic and Activating Factor (MCAF) produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8607 Dalton.
Description: Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1) and small inducible cytokine A2. CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury, infection, and inflammation.
Species: Human
Source: E.coli
Form: Human MCP-1 is lyopohilized with no additives.
Purity: Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity: MCP-1 is fully biologically active when compared to standard. The specific activity as determined by the ability of MCP-1 to chemoattract human monocytes using a concentration of 4-15 ng/ml.
Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg"s/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by: UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level: Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT
Storage: Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name: CCL2 chemokine (C-C motif) ligand 2 [ Homo sapiens ]
Official Symbol: CCL2
Synonyms: chemokine (C-C motif) ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; MGC9434; CCL2; 17q11.2-q12; small inducible cytokine A2; monocyte secretory protein JE; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; small inducible cytokine subfamily A (Cys-Cys), member 2; monocyte chemotactic protein 1, homologous to mouse Sig-je; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); MCAF; MCP1; Monocyte chemoattractant protein 1; Small-inducible cytokine A2; chemokine (C-C motif) ligand 2; small inducible cytokine A2 (monocyte chemotactic protein 1,homologous to mouse Sig-je).
Gene ID: 6347
mRNA Refseq: NM_002982
Protein Refseq: NP_002973
MIM: 158105
UniProt ID: P13500
Chromosome Location: 17q11.2-q12
Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
Function: signal activity; protein kinase activity; heparin binding; chemokine activity; G-protein-coupled receptor binding; CCR2 chemokine receptor binding

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