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Recombinant Mouse Chemokine (C-C motif) Ligand 2

Cat. No. : Ccl2-282M
Product Overview : Recombinant Murine JE(MCP-1) produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 125 amino acids and having a molecular mass of 13803 Dalton.
Description : Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1) and small inducible cytokine A2. CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury, infection, and inflammation.
Species : Mouse
Source : E.coli
Form : Lyophilized with no additives.
Purity : Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity : Murine JE(MCP-1)is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract Balb/C mouse spleen MNCs at 1.0-20.0 ng/ml.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mgμs/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 98% as determined by : Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by : UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Amino acid sequence : QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEW-V QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVK-LTRKS EANASTTFST TTSSTSVGVT SVTVN
Storage : Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Pathways : Chemokine signaling pathway; Cytokine-cytokine receptor interaction
PDB rendering based on 1dok. :

Gene Name : Ccl2 chemokine (C-C motif) ligand 2 [ Mus musculus ]
Official Symbol : Ccl2
Synonyms : Ccl2; chemokine (C-C motif) ligand 2; JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF; AI323594; monocyte chemoattractant protein-1; monocyte chemotactic protein; OTTMUSP00000000786; small inducible cytokine A2; monocyte chemotactic protein
Gene ID : 20296
mRNA Refseq : NM_011333
Protein Refseq : NP_035463
UniProt ID : P10148
Chromosome Location : 11 C-E1; 11 46.5 cM
Function : G-protein-coupled receptor binding; chemokine activity; cytokine activity; protein binding

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