"CCL3" Related Products

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Recombinant Human Chemokine (C-C motif) Ligand 3

Cat. No.: CCL3-291H
Product Overview: Recombinant Human MIP-1 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7820 Dalton.
Description: CCL3, also known as Macrophage inflammatory protein-1μ (MIP-1μ), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes. Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.
Species: Human
Source: E.coli
Form: Lyopohilized with no additives.
Purity: Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity: Determined by its ability to chemoattract human monocytes using a concentration range of 0.5 - 8 ng/ml.
Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mgμs/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by: UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level: Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence: ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Storage: Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name: CCL3 chemokine (C-C motif) ligand 3 [ Homo sapiens ]
Official Symbol: CCL3
Synonyms: CCL3; chemokine (C-C motif) ligand 3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha; LD78 alpha beta; small inducible cytokine A3 (homologous to mouse Mip-1a); SIS-beta; G0/G1 switch regulatory protein 19-1; G0S19-1 protein; LD78 alpha beta; Macrophage inflammatory protein 1-alpha; PAT 464.1; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; C-C motif chemokine 3; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein
Gene ID: 6348
mRNA Refseq: NM_002983
Protein Refseq: NP_002974
MIM: 182283
UniProt ID: P10147
Chromosome Location: 17q11-q21
Pathway: Cytokine-cytokine receptor; Toll-like receptor signaling pathway; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Chagas disease (American trypanosomiasis); Chemokine receptors bind chemokines; GPCR ligand binding; IL12-mediated signaling events; Peptide ligand-binding receptors; Rheumatoid arthritis; Salmonella infection; Senescence and Autophagy
Function: chemoattractant activity; chemokine activity; signal transducer activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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