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Recombinant Human CD6 Molecule, His-tagged

Cat.No. : CD6-4759H
Product Overview : CD6 was fused with a C-terminal 6 His tag and has a calculated MW of 68.2 KDa expressed. Protein migrates as 110 kDa in reduced SDS-PAGE resulting from glycosylation.
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Cat. No. : CD6-4759H
Description : CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF). CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. CD6 appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor. Studies demonstrating a mitogenic effect for T cells with some CD6 specific monoclonal antibodies, in conjunction with either accessory cells or PMA and antiCD2 mAb, support the concept of CD6 as a co stimulatory molecule.
Source : Recombinant human CD6 /TP120 His18 -Glu398 (Accession Q8WWJ7) fused with a C-terminal His tag was produced in human HEK293 cells
Species : Human
Form : Bulk protein in a 0.22 μm filtered solution of PBS, pH7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Purity : >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
Endotoxin : Less than 1.0 EU per 1 μg of the rhCD6 by the LAL method.
Storage : Store at -80°C upon received. Avoid repeated freeze-thaw cycles.
Gene Name : CD6 CD6 molecule [ Homo sapiens ]
Official Symbol : CD6
Synonyms : CD6; CD6 molecule; TP120; FLJ44171; CD6 antigen; T-cell differentiation antigen CD6; T12; OTTHUMP00000236965; OTTHUMP00000236967; OTTHUMP00000236969; OTTHUMP00000236970; OTTHUMP00000236971
Gene ID : 923
mRNA Refseq : NM_006725
Protein Refseq : NP_006716
MIM : 186720
UniProt ID : P30203
Chromosome Location : 11q13
Pathway : Cell adhesion molecules (CAMs)
Function : scavenger receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses? 02/18/2022

CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases? 07/19/2021

CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process? 04/01/2020

CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation? 09/28/2019

CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses? 11/05/2018

CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.

Customer Reviews (3)

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Reviews
04/05/2021

    Fantastic customer support. They genuinely care about the success of our research.

    11/11/2020

      Quality you can trust. Our lab has seen improved precision since using this product.

      07/27/2019

        Shipping is always on time, and the packaging ensures the product arrives in perfect condition.

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