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Active Recombinant Mouse Cystatin B, His-tagged

Cat.No. : Cstb-4002M
Product Overview : A DNA sequence encoding the mouse CTSB ( P10605 ) ( Met 1 - Phe 339 ) was fused with a polyhistidine tag at the C-terminus.
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Cat. No. : Cstb-4002M
Description : Mouse cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to the cystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures.
Source : Mouse
Host : Human Cells
Form : Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Purity : > 95 % as determined by SDS-PAGE
Bio-activity : Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC ( R&D Systems, Catalog # ES008 ). The specific activity is > 1,000 pmoles / min / µg
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70μ
Predicted N terminal : His 18
Molecular Mass : The secreted recombinant mouse CTSB ( pro form ) consists of 333 amino acids and has a predicted molecular mass of 36.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CTSB is approximately 35-43 kDa due to glycosylation
Storage : Store it under sterile conditions at -70μ. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : Cstb cystatin B [ Mus musculus ]
Official Symbol : Cstb
Synonyms : Cstb; Stfb; AA960480; cystatin B; cystatin-B; stefin-B
Gene ID : 13014
mRNA Refseq : NM_007793
Protein Refseq : NP_031819
UniProt ID : Q62426
Chromosome Location : 10 C1; 10 42.0 cM
Function : cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; peptidase inhibitor activity; protease binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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