Active Recombinant Mouse Cystatin B, His-tagged
Cat.No. : | Cstb-4002M |
Product Overview : | A DNA sequence encoding the mouse CTSB ( P10605 ) ( Met 1 - Phe 339 ) was fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
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Cat. No. : | Cstb-4002M |
Description : | Mouse cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to the cystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. |
Source : | Mouse |
Host : | Human Cells |
Form : | Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
Purity : | > 95 % as determined by SDS-PAGE |
Bio-activity : | Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC ( R&D Systems, Catalog # ES008 ). The specific activity is > 1,000 pmoles / min / µg |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Stability : | Samples are stable for up to twelve months from date of receipt at -70μ |
Predicted N terminal : | His 18 |
Molecular Mass : | The secreted recombinant mouse CTSB ( pro form ) consists of 333 amino acids and has a predicted molecular mass of 36.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CTSB is approximately 35-43 kDa due to glycosylation |
Storage : | Store it under sterile conditions at -70μ. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | Cstb cystatin B [ Mus musculus ] |
Official Symbol : | Cstb |
Synonyms : | Cstb; Stfb; AA960480; cystatin B; cystatin-B; stefin-B |
Gene ID : | 13014 |
mRNA Refseq : | NM_007793 |
Protein Refseq : | NP_031819 |
UniProt ID : | Q62426 |
Chromosome Location : | 10 C1; 10 42.0 cM |
Function : | cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; peptidase inhibitor activity; protease binding |
Products Types
◆ Recombinant Protein | ||
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CSTB-2037M | Recombinant Mouse CSTB Protein, His (Fc)-Avi-tagged | +Inquiry |
Cstb-2347M | Recombinant Mouse Cstb Protein, Myc/DDK-tagged | +Inquiry |
CSTB-1305R | Recombinant Rat CSTB Protein, His (Fc)-Avi-tagged | +Inquiry |
CSTB-895R | Recombinant Rhesus Macaque CSTB Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CSTB-7224HCL | Recombinant Human CSTB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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