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Recombinant Mouse Cystatin B, His-tagged

Cat. No. : Cstb-4002M
Product Overview : A DNA sequence encoding the mouse CTSB ( P10605 ) ( Met 1 - Phe 339 ) was fused with a polyhistidine tag at the C-terminus.
Description : Mouse cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to the cystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures.
Source : Mouse
Host : Human Cells
Form : Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Purity : > 95 % as determined by SDS-PAGE
Bio-activity : Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC ( R&D Systems, Catalog # ES008 ). The specific activity is > 1,000 pmoles / min / µg
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70μ
Predicted N terminal : His 18
Molecular Mass : The secreted recombinant mouse CTSB ( pro form ) consists of 333 amino acids and has a predicted molecular mass of 36.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CTSB is approximately 35-43 kDa due to glycosylation
Storage : Store it under sterile conditions at -70μ. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : Cstb cystatin B [ Mus musculus ]
Official Symbol : Cstb
Synonyms : Cstb; Stfb; AA960480; cystatin B; cystatin-B; stefin-B
Gene ID : 13014
mRNA Refseq : NM_007793
Protein Refseq : NP_031819
UniProt ID : Q62426
Chromosome Location : 10 C1; 10 42.0 cM
Function : cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; peptidase inhibitor activity; protease binding

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