Recombinant Human Glycerol-3-Phosphate Dehydrogenase 2 (Mitochondrial)
Cat.No. : | GPD2-1310H |
Product Overview : | GPD2 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 558 amino acids fragment (43-600) corresponding to the GlpA domain fragment of the mature protein, having a total molecular mass of 64kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The GPD2 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
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Cat. No. : | GPD2-1310H |
Description : | GPD2 (Mitochondrial glycerol-3-phosphate dehydrogenase) is a Ca2+-sensitive, FAD-binding protein, which is located on the outer surface of the inner mitochondrial membrane. Two isoforms have been identified for mGPD: Isoform 1 is comprised of 727 a.a. residues, while isoform 2 lacks 126 a.a. residues of the N-terminus. GPD2 catalyses the oxidation of glycerol-3-phosphate to DHAP (dihydroxyacetone phosphate) with associated reduction of the enzyme-bound FAD. GPD2 is a testis-specific promoter of mitochondrial GPDH. GPD2 along with a cytosolic NAD-linked GPD forms the glycerol phosphate shuttle that uses the interconversion of G-3-P and DHAP to transfer reducing equivalents into mitochondria, which results in the reoxidation of NADH produced during glycolysis. GPD2 deficiency contributes to the impairment of glucose-stimulated insulin discharge in a number of animal models of non-insulin dependent diabetes mellitus. GPD2 up-regulation as a result of a highly glycolytic environment contributes to the general increase in ROS generation and may lead to the progression of prostate cancer. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | GPD2 protein is supplied in 1x PBS and 50% glycerol. |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Physical Appearance : | Sterile Filtered clear solution. |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
Gene Name : | GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) [ Homo sapiens ] |
Official Symbol : | GPD2 |
Synonyms : | GPD2; glycerol-3-phosphate dehydrogenase 2 (mitochondrial); GDH2; GPDM; mGPDH; glycerol-3-phosphate dehydrogenase 2, mitochondrial; EC 1.1.5.3; GDH2; GPD-M; GPDH-M; GPDM; mGPDH; mtGPD; mitochondrial glycerophosphate dehydrogenase. |
Gene ID : | 2820 |
mRNA Refseq : | NM_000408 |
Protein Refseq : | NP_000399 |
MIM : | 138430 |
UniProt ID : | P43304 |
Chromosome Location : | 2q24.1 |
Pathway : | Glycerophospholipid metabolism |
Function : | calcium ion binding; glycerol-3-phosphate dehydrogenase activity; oxidoreductase activity |
Products Types
◆ Recombinant Protein | ||
GPD2-3830M | Recombinant Mouse GPD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
GPD2-2290R | Recombinant Rat GPD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
GPD2-5153H | Recombinant Human GPD2 Protein, GST-tagged | +Inquiry |
GPD2-1752R | Recombinant Rhesus Macaque GPD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
GPD2-1932R | Recombinant Rhesus monkey GPD2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GPD2-733HCL | Recombinant Human GPD2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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