Recombinant Human Interleukin 1, Beta IL1B-461H

Recombinant Human Interleukin 1, Beta

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Human Interleukin 1, Beta

Recombinant Human Interleukin 1, Beta

IL1B Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : IL1B-461H
Product Overview : Interleukin-1beta (IL-1μ) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendric cells (DCs). IL-1μ and IL-1μ are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1μ is cell associated and IL-1μ is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. Recombinant human IL-1μ is a non-glycosylated single chain 17,376 Da protein containing 153 amino acid residues.
Description : The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.
Species : Human
Source : E.coli
Form : Lyopohilized from 10 mM NaP, pH 7.5.
Purity : Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity : Human IL-1μ is fully biologically active when compared to a standard. The ED 50 , as determined by the dose-dependent proliferation of mouse D10S cells, is 1 pg/ml.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mgμs/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 97% as determined by : Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by : UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level : Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence : APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
Storage : Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name : IL1B interleukin 1, beta [ Homo sapiens ]
Official Symbol : IL1B
Synonyms : IL1B; interleukin-1 beta; IL-1; IL1F2; IL1-BETA; IL-1 beta; catabolin; OTTHUMP00000162031; preinterleukin 1 beta; pro-interleukin-1-beta
Gene ID : 3553
mRNA Refseq : NM_000576
Protein Refseq : NP_000567
MIM : 147720
UniProt ID : P01584
Chromosome Location : 2q14
Pathway : African trypanosomiasis; Alzheimer"s disease; Amoebiasis; Apoptosis; Cellular roles of Anthrax toxin; Chagas disease (American trypanosomiasis); Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction; Cytokines and Inflammatory Response; Cytosolic DNA-sensing pathway; Graft-versus-host disease; Hematopoietic cell lineage; IFN-gamma pathway; IL12-mediated signaling events; Immune System; Interleukin-1 signaling
Function : interleukin-1 receptor binding; protein binding; signal transducer activity; cytokine activity; growth factor activity

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy