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Recombinant Human Neurexin 3

Cat. No. : NRXN3-014H
Product Overview : A DNA sequence encoding the human NRXN3 isoform 2 (NP_620426.2) extracellular domain (Met 1-Thr 357) was fused with the Fc region of human IgG1 at the C-terminus.
Description : NRXN3 is a single-pass type I membrane protein which belongs to the neurexin family. It contains one laminin G-like domain. It is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion. Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors.
Source : Human
Host : Human Cells
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Purity : > 95 % as determined by SDS-PAGE
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. When 5x104 cells/well are added to NRXN3 coated plates (0.8 μg/mL and 100 μL/well), approximately 30%-50% will adhere specifically after 60 minutes at 37°C
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal : Ser 36
Molecular Mass : The secreted recombinant human NRXN3/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 563 amino acids and predictes a molecular mass of 61.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NRXN3/Fc monomer is approximately 75-85 kDa due to glycosylation.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : NRXN3 neurexin 3 [ Homo sapiens ]
Official Symbol : NRXN3
Synonyms : NRXN3; neurexin 3; C14orf60; KIAA0743; MGC176711; neurexin-3-beta; neurexin III; neurexin III-beta; neurexin III-alpha
Gene ID : 9369
mRNA Refseq : NM_138970
Protein Refseq : NP_620426
MIM : 600567
UniProt ID : Q9HDB5
Chromosome Location : 14q31
Pathway : Cell adhesion molecules (CAMs)
Function : metal ion binding; receptor activity

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