Recombinant Human Platelet-Derived Growth Factor Receptor, Beta Polypeptide, His-tagged
Cat.No. : | PDGFRB-4758H |
Product Overview : | Recombinant human PDGFRB contains C-terminal polyhistidine tag and has a calculated MW of 60.3 KDa. As a result of glycosylation, DTT-reduced protein migrates as 95-100 kDa polypeptide in SDS-PAGE. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PDGFRB-4758H |
Description : | Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is receptor that binds specifically to PDGFB and has a tyrosine-protein kinase activity. Is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (A, B, C and D). The receptors PDGFRA and PDGFRB are related in sequence and both are members of the class III subtype of receptor tyrosine kinases (RTKs). Other class III RTKs are CSF1R, KIT and FLT3. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the μ and μ receptors is independently regulated in various cell types. |
Source : | Recombinant human PDGFRB Met1-Phe530 (Accession NP_002600) was produced in human HEK293 cells. |
Species : | Human |
Form : | Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization. |
Purity : | >95% as determined by SDS-PAGE. All lots are greater than 95% pure. |
Endotoxin : | Less than 1.0 EU per 1 μg of the human PDGFRB by the LAL method. |
Storage : | Store at -70°C upon received. Avoid repeated freeze-thaw cycles. |
Gene Name : | PDGFRB platelet-derived growth factor receptor, beta polypeptide [ Homo sapiens ] |
Official Symbol : | PDGFRB |
Synonyms : | PDGFRB; platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR; CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; CD140 antigen-like family member B; EC 2.7.10.1; CD140b; CD140b antigen; soluble PDGFRb variant; beta-type platelet-derived growth factor receptor; OTTHUMP00000160528 |
Gene ID : | 5159 |
mRNA Refseq : | NM_002609 |
Protein Refseq : | NP_002600 |
MIM : | 173410 |
UniProt ID : | P09619 |
Chromosome Location : | 5q33.1 |
Pathway : | Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Melanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton |
Function : | ATP binding; nucleotide binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor receptor binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
Products Types
◆ Recombinant Protein | ||
PDGFRB-33H | Active Recombinant Human PDGFRB Protein, His-tagged, Biotinylated | +Inquiry |
PDGFRB-4000R | Recombinant Rat PDGFRB Protein, His (Fc)-Avi-tagged | +Inquiry |
PDGFRB-2058H | Recombinant Human PDGFRB Protein, Fc/His-tagged | +Inquiry |
PDGFRB-416H | Recombinant Human PDGFRB Protein, Fc-tagged | +Inquiry |
Pdgfrb-10607M | Recombinant Mouse Pdgfrb Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PDGFRB-1112RCL | Recombinant Rat PDGFRB cell lysate | +Inquiry |
PDGFRB-1107HCL | Recombinant Human PDGFRB cell lysate | +Inquiry |
PDGFRB-1046CCL | Recombinant Cynomolgus PDGFRB cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1618 | PDGFRb Functional Assay Kit | +Inquiry |
Kit-1617 | U2OS PDGFRb Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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