Recombinant Human Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2), His-tagged

• Cat.No.: RAC2-4536H
• Product Overview: RAC2 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 209 amino acids (1- 189 a.a.) and having a molecular mass of 23.3kDa. The RAC2 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: RAC2-4536H
• Description: RAC2 is a small signaling G protein/GTPase which is part of the RAS superfamily of small GTP-binding proteins which regulate cell growth, actin cytoskeletal organization, cell proliferation, survival, cell cycle progression, gene transcription rgulation and the activation of protein kinases. RAC2 cycles between an active gtp-bound and inactive gdp-bound state. In active state, RAC2 binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. RAC2 is involved in the regulation of the nadph oxidase.
• Source: Human
• Host: Escherichia Coli.
• Form: The RAC2 solution contains 20mM Tris-HCl buffer (pH 8.0), 20% Glycerol, 2mM EDTA, 2mM DTT and 0.1M NaCl.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Physical Appearance: Sterile Filtered colorless solution.
• Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRAC
• Storage: RAC2 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [ Homo sapiens ]
• Official Symbol: RAC2
• Synonyms: RAC2; Gx; EN-7; HSPC022; ras-related C3 botulinum toxin substrate 2; p21-Rac2; small G protein; OTTHUMP00000197775; OTTHUMP00000197777; OTTHUMP00000197778; OTTHUMP00000197779; rho family, small GTP binding protein Rac2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)
• Gene ID: 5880
• mRNA Refseq: NM_002872
• Protein Refseq: NP_002863
• MIM: 602049
• UniProt ID: P15153
• Chromosome Location: 22q13.1
• Pathway: Adherens junction; Axon guidance; B cell receptor signaling pathway; Chemokine signaling pathway; Colorectal cancer; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Leukocyte transendothelial migration; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Pancreatic cancer; Pathways in cancer; Regulation of actin cytoskeleton; VEGF signaling pathway; Wnt signaling pathway; Signaling by Rho GTPases
• Function: GTP binding; GTPase activity; nucleotide binding; protein binding