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Active Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 13B

Cat.No. : TNFSF13B-301H
Product Overview : The TNF-related ligand, B cell-activating factor belonging to the TNF family (BAFF), is necessary for normal B cell development and survival, and specifically binds the receptors transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), B cell maturation Ag (BCMA), and BAFF-R.Using specific mAbs, Recombinant Human B Lymphocyte Stimulator produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton.
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Cat. No. : TNFSF13B-301H
Description : B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFLSF13B gene.
Species : Human
Source : E.coli
Form : Each mg contains 1.6mg mannitol and 1.2mg HSA.
Purity : Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity : Recombinant B Lymphocyte Stimulator is fully biologically active when compared to standard. The activity is determined by the dose-dependant stimulation of IL-8 production by human PBMC. The ED50 for this effect is less than 10ng/ml. Please note: results may vary with PBMC donors.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mgμs/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 98% as determined by : Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by : UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level : Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence : MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
Storage : Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name : TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b [ Homo sapiens ]
Official Symbol : TNFSF13B
Synonyms : TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; TNFSF13B; Tumor necrosis factor ligand superfamily member 13B; TNF- and APOL-related leukocyte expressed ligand 1; B lymphocyte stimulator; B cell-activating factor; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form
Gene ID : 10673
mRNA Refseq : NM_001145645
Protein Refseq : NP_001139117
MIM : 603969
UniProt ID : Q9Y275
Chromosome Location : 13q32-q34
Pathway : Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Rheumatoid arthritis
Function : cytokine activity; tumor necrosis factor receptor binding; protein binding; receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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