"TPO" Related Products


Recombinant Human Thyroid Peroxidase

Cat. No.: TPO-1487H
Product Overview: Thyroid Peroxidase Human Recombinant produced in SF9 is a glycosylated, polypeptide chain containing 834 amino acids and having a molecular mass of 92,872 Dalton (excluding glycosylation), 101 kDa total mass.The TPO is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
Description: Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called `microsomal antigen` has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx.
Source: Human
Host: Sf9 insect cells.
Form: TPO is supplied in 16mM HEPES pH-7.6, 160mM NaCl, 0.08mM Kl and 20% glycerol.
Purity: Greater than 95.0% as determined by SDS-PAGE.
Gene Name: TPO thyroid peroxidase [ Homo sapiens ]
Official Symbol: TPO
Synonyms: TPO; thyroid peroxidase; TPX; TDH2A; MSA; thyroperoxidase; EC; EC 1.11.1; OTTHUMP00000115535; OTTHUMP00000115536
Gene ID: 7173
mRNA Refseq: NM_000547
Protein Refseq: NP_000538
MIM: 606765
UniProt ID: P07202
Chromosome Location: 2p25
Pathway: Amine-derived hormones; Autoimmune thyroid disease; Biosynthesis of amine and peptide hormones; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Metabolic pathways; Metabolism of amino acids and derivatives; hyroxine biosynthesis; Tyrosine metabolism
Function: calcium ion binding; heme binding; iodide peroxidase activity; oxidoreductase activity; peroxidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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