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Recombinant Human Uroplakin 3A, His-tagged

Cat.No. : UPK3A-4747H
Product Overview : Recombinant human UPK3A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
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Cat. No. : UPK3A-4747H
Description : UPK3A belongs to the uroplakin-3 family. Uroplakins (UP) are key components of the urothelium. They are transmembrane proteins that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both belonging to the "tetraspanin" family). All have large luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic portions in their C-termini. UPK3A is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Mutations in this gene may be associated with renal adysplasia
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 150mM NaCl
Molecular Weight : 23.1kDa (214aa), confirmed by MALDI-TOF
Purity : > 90% by SDS - PAGE
Concentration : 0.25mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : UPK3A uroplakin 3A [ Homo sapiens ]
Official Symbol : UPK3A
Synonyms : UPK3A; UP3A; UPK3; UPIII; UPIIIA; MGC119178; uroplakin-3a; uroplakin III; OTTHUMP00000199859; OTTHUMP00000199860; uroplakin 3A; Uroplakin III; uroplakin 3; UP3a
Gene ID : 7380
mRNA Refseq : NM_006953
Protein Refseq : NP_008884
MIM : 611559
UniProt ID : O75631
Chromosome Location : 22q13.31

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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