"UPK3A" Related Products

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Recombinant Human Uroplakin 3A, His-tagged

Cat. No. : UPK3A-4747H
Product Overview : Recombinant human UPK3A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Description : UPK3A belongs to the uroplakin-3 family. Uroplakins (UP) are key components of the urothelium. They are transmembrane proteins that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both belonging to the "tetraspanin" family). All have large luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic portions in their C-termini. UPK3A is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Mutations in this gene may be associated with renal adysplasia
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 150mM NaCl
Molecular Weight : 23.1kDa (214aa), confirmed by MALDI-TOF
Purity : > 90% by SDS - PAGE
Concentration : 0.25mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : UPK3A uroplakin 3A [ Homo sapiens ]
Official Symbol : UPK3A
Synonyms : UPK3A; UP3A; UPK3; UPIII; UPIIIA; MGC119178; uroplakin-3a; uroplakin III; OTTHUMP00000199859; OTTHUMP00000199860; uroplakin 3A; Uroplakin III; uroplakin 3; UP3a
Gene ID : 7380
mRNA Refseq : NM_006953
Protein Refseq : NP_008884
MIM : 611559
UniProt ID : O75631
Chromosome Location : 22q13.31

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