Recombinant Human Vimentin, GST-tagged
Cat.No. : | VIM-4679H |
Product Overview : | Vimentin Human Recombinant GST Tag full length protein is produced in E.Coli, having a molecular weight of 86kDa (determined by SDS gel elctrophoresis). |
- Specification
- Gene Information
- Related Products
Cat. No. : | VIM-4679H |
Description : | Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines. Vimentin is the main intermediate filament protein in mesenchymal cells and is therefore of value in the differential diagnosis of undifferentiated neoplasms. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | The Vimentin protein solution contains 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. |
Physical Appearance : | Sterile filtered colorless solution. |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
Gene Name : | VIM vimentin [ Homo sapiens ] |
Official Symbol : | VIM |
Synonyms : | VIM; FLJ36605; Vimentin; OTTHUMP00000019224 |
Gene ID : | 7431 |
mRNA Refseq : | NM_003380 |
Protein Refseq : | NP_003371 |
MIM : | 193060 |
UniProt ID : | P08670 |
Chromosome Location : | 10p13 |
Pathway : | Apoptosis; Muscle contraction |
Function : | Protein C-terminus bindin; Protein kinase binding; Structural constituent of cytoskeleton |
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◆ Native Protein | ||
WIM-5415B | Native Bovine Vimentin | +Inquiry |
VIM-186B | Native bovine VIM | +Inquiry |
◆ Lysates | ||
VIM-1907HCL | Recombinant Human VIM cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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