Active Recombinant Human BDNF

• Cat.No.: BDNF-003H
• Product Overview: Human BDNF (P23560, 129 a.a. - 247 a.a.) partial recombinant protein expressed in Escherichia coli.

Specification

• Cat. No.: BDNF-003H
• Description: Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene.BDNF is a member of the "neurotrophin" family of growth factors, which are related to the canonical "Nerve Growth Factor", NGF. Neurotrophic factors are found in the brain and the periphery.
• Sequence: HS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT LTIKRGR
• Theoretical MW (kDa): 14
• Form: Lyophilized
• Preparation Method: E. coli expression system
• Purity: > 97% by SDS-PAGE and HPLC
• Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
• Activity: The ED50 was determined by the dose-dependent proliferation of rat C6 cells, and was found to be in the range of 0.5 ug/mL.
• Application: SDS-PAGE
• Storage Buffer: Lyophilized from citric acid, pH 5.7
• Storage: Store at -20°C on dry atmosphere for 2 years.After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P23560
• Pathways: Huntington"s disease; MAPK signaling pathway; Neurotrophin signaling pathway
• Publication:
  Generation of dopamine neuronal-like cells from induced neural precursors derived from adult human cells by non-viral expression of lineage factors (2018)

Gene Information

• Gene Name: BDNF brain-derived neurotrophic factor [ Homo sapiens ]
• Official Symbol: BDNF
• Synonyms: BDNF; brain-derived neurotrophic factor; MGC34632; abrineurin; neurotrophin; OTTHUMP00000232005; OTTHUMP00000232006; OTTHUMP00000232013; OTTHUMP00000232014; OTTHUMP00000232015; OTTHUMP00000232016; OTTHUMP00000232018; OTTHUMP00000232019; OTTHUMP00000232020; OTTHUMP00000232021; OTTHUMP00000232022; OTTHUMP00000232039; OTTHUMP00000232040; OTTHUMP00000232041; OTTHUMP00000232043
• Gene ID: 627
• mRNA Refseq: NM_001143806
• Protein Refseq: NP_001137278
• MIM: 113505
• Chromosome Location: 11p13
• Function: Growth factor activity