BDNF

  • Official Full Name

    brain-derived neurotrophic factor

  • Overview

    The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimers and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
  • Synonyms

    BDNF; brain-derived neurotrophic factor; ANON2; BULN2; abrineurin; neurotrophin;

  • Recombinant Proteins
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Cell & Tissue Lysates
  • Cattle
  • Chicken
  • Dog
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • CHO
  • CHO-K1
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • Myc
  • His|GST
  • SUMO
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BDNF-003H Active Recombinant Human BDNF Human N/A
Human BDNF-022H Active Recombinant Human Brain Derived Neurotrophic Factor E.coli N/A
Human BDNF-01HG Active GMP Recombinant Human BDNF Protein CHO-K1
Human BDNF-72H Recombinant Human BDNF protein CHO N/A
Human BDNF-243H Recombinant Human BDNF protein, His-tagged E.coli His
Human BDNF-258H Recombinant Human BDNF protein E.coli N/A
Human BDNF-187H Recombinant Human BDNF Protein, GST-tagged Wheat Germ GST
Human BDNF-188H Recombinant Human BDNF Protein, GST-tagged Wheat Germ GST
Human BDNF-549H Recombinant Human BDNF protein, GST-tagged E.coli GST
Human BDNF-10202H Recombinant Human BDNF, GST-tagged E.coli GST
Human BDNF-334H Recombinant Human Brain-derived Neurotrophic Factor Sf21 Insect Cell N/A
Human BDNF-231H Recombinant Human Brain-derived Neurotrophic Factor, His-tagged E.coli His
Human BDNF-491H Recombinant Human BDNF protein, His-tagged HEK293 His
Human BDNF-22H Recombinant Human BDNF Protein, His-tagged HEK293 His
Human BDNF-1079H Recombinant Human BDNF protein, Myc-tagged E.coli Myc
Human BDNF-2466H Recombinant Human BDNF Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BDNF-113HG Active GMP Recombinant Human BDNF Protein Insect Cell N/A
Human BDNF-2585H Recombinant Human BDNF protein, His-SUMO-tagged E.coli His-SUMO
Human BDNF-01H Recombinant Active Human BDNF Protein, His-tagged E.coli His
Human BDNF-3171H Recombinant Human BDNF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BDNF-2555H Recombinant Human BDNF protein, His-tagged E.coli His
Human BDNF-2586H Recombinant Human BDNF protein, GST-tagged E.coli GST
Human BDNF-08H Recombinant Active Human BDNF Protein, His-tagged(C-ter) E.coli His(C-ter)
Human BDNF-007H Active Recombinant Human BDNF Protein E. coli
Human BDNF-444H-B Recombinant Human BDNF Protein Pre-coupled Magnetic Beads HEK293
Human BDNF-1566HF Recombinant Full Length Human BDNF Protein, GST-tagged In Vitro Cell Free System GST
Human BDNF-143H Active Recombinant Human BDNF Protein E.coli
Human BDNF-1105H Recombinant Human BDNF protein, His-Myc-tagged E.coli His/Myc
Human BDNF-312H Recombinant Human BDNF Protein, His-tagged E.coli N-His
Human BDNF-1696HF Recombinant Full Length Human BDNF Protein, GST-tagged In Vitro Cell Free System GST
Human BDNF-298B Active Recombinant Human BDNF Protein CHO
Human BDNF-02H Recombinant Human BDNF Protein, His-tagged HEK293 His
Human BDNF-266H Active Recombinant Human BDNF Protein (His132-Arg250), C-His tagged, Animal-free, Carrier-free E.coli C-His
Human BDNF-04H Active Recombinant Human BDNF Protein E.coli
Human BDNF-3372H Recombinant Human BDNF protein, His-tagged HEK293 His
Human BDNF-144H Active Recombinant Human BDNF Protein E.coli
Human BDNF-1377H Recombinant Human BDNF Protein (Arg128-Arg247), N-His tagged E.coli N-His
Human BDNF-454HFL Recombinant Full Length Human BDNF Protein, C-Flag-tagged Mammalian cells Flag
Human BDNF-5075H Recombinant Human BDNF Protein (His129-Arg247), C-His tagged Insect Cells C-His
Human BDNF-444H Recombinant Human BDNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BDNF-155H Human Brain-derived Neurotrophic Factor (rDNA derived) Reference standard E.coli N/A
Mouse Bdnf-7392M Recombinant Mouse Bdnf, None tagged CHO N/A
Mouse Bdnf-550M Recombinant Mouse Bdnf protein, His & GST-tagged E.coli His/GST
Mouse BDNF-001MCL Recombinant Mouse BDNF cell lysate CHO N/A
Mouse Bdnf-703M Recombinant Mouse Bdnf Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Bdnf-310M Recombinant Mouse Bdnf Protein, His-tagged E.coli N-His
Mouse BDNF-9843M Active Recombinant Mouse BDNF protein, His-tagged HEK293 His
Mouse Bdnf-736M Recombinant Mouse Bdnf protein E.coli N/A
Rat BDNF-966R Recombinant Rat BDNF Protein Mammalian Cell His
Rat Bdnf-552R Recombinant Rat Bdnf protein, His-tagged E.coli His
Rat Bdnf-5302R Recombinant Rat Bdnf protein, His-tagged E.coli His
Rat BDNF-624R Recombinant Rat BDNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BDNF-624R-B Recombinant Rat BDNF Protein Pre-coupled Magnetic Beads HEK293
Rabbit BDNF-553R Recombinant Rabbit BDNF protein, His-tagged E.coli His
Dog BDNF-545D Recombinant Dog BDNF protein, His-tagged E.coli His
Cattle BDNF-311C Recombinant Cattle BDNF Protein, His-tagged E.coli N-His
Guinea pig Bdnf-548G Recombinant Guinea pig Bdnf protein, His & GST-tagged E.coli His/GST
Horse BDNF-546H Recombinant Horse BDNF protein, His-tagged E.coli His
Zebrafish BDNF-9136Z Recombinant Zebrafish BDNF Mammalian Cell His
Pig BDNF-551P Recombinant Pig BDNF protein, His-tagged E.coli His
Chicken BDNF-547C Recombinant Chicken BDNF protein, His-tagged E.coli His
Chicken BDNF-3252C Recombinant Chicken BDNF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BDNF Related Articles
  • BDNF Related Gene Family
  • BDNF Related Research Area

BDNF involved in several pathways and played different roles in them. We selected most pathways BDNF participated on our site, such as MAPK signaling pathway, cAMP signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAX;MYCB;NTF3;GRB2A;FOS;FGFR1A;NFKB2;FGF7;PDGFAA
cAMP signaling pathwayGRIA4;GPR81;PIK3CA;PPP1CA;GRIN3A;CALML3;SLC9A1;ATP2B4;CAMK2A
Neurotrophin signaling pathwaySH2B1;NTF4;ABL1;PRKCD;MAPK8;CAMK2A;NTRK2;SHC1;CALML3
Huntingtons diseaseUCP1;CREB3L2;PLCB4;DNAL1;NDUFA3;NDUFA12;NDUFS2;UQCR10;NDUFC1
Cocaine addictionCREB3L2;RGS9;GNAI2;CDK5;CREB3L1;NFKB1;DDC;DRD1A;DRD2
AlcoholismHIST1H3A;GRIN2A;HIST1H2BD;SHC4;HIST3H2BB-PS;GNAI2;GM6026;HDAC7;GRIN3A

BDNF has several biochemical functions, for example, growth factor activity, neurotrophin TRKB receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BDNF itself. We selected most functions BDNF had, and list some proteins which have the same functions with BDNF. You can find most of the proteins on our site.

Function Related Protein
growth factor activityEGF;BDNF;NTF7;FGF18B;CECR1A;PPBP;FGF5;PDGFAA;NODAL
neurotrophin TRKB receptor bindingEFNA5;BDNF

BDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of BDNF.

NTF3; SORCS2; NTF4; JUNB; INPP5K; AGO3; F11R

Nam, JH; Leem, E; et al. Induction of GDNF and BDNF by hRheb(S16H) Transduction of SNpc Neurons: Neuroprotective Mechanisms of hRheb(S16H) in a Model of Parkinson's Disease. MOLECULAR NEUROBIOLOGY 51:487-499(2015).
Jeon, MT; Nam, JH; et al. In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production. MOLECULAR THERAPY 23:445-455(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is BDNF measured in clinical settings? 10/26/2021

BDNF levels can be measured through blood tests or cerebrospinal fluid analysis, providing insights into the protein's concentration in the body.

What neurological disorders are associated with BDNF deficiency? 10/03/2018

BDNF deficiency has been linked to conditions such as Alzheimer's disease, Parkinson's disease, and depression.

Are there medications that target BDNF for clinical use? 08/02/2018

While there are no direct BDNF medications, certain drugs and treatments aim to enhance BDNF levels indirectly, offering potential therapeutic benefits.

How does physical exercise influence BDNF levels, and what implications does this have for clinical applications? 06/24/2017

Physical exercise has been shown to increase BDNF production, suggesting that exercise could be used as a non-pharmacological intervention to support neurological health.

What role does BDNF play in synaptic plasticity, and how does it impact learning and memory? 01/28/2016

BDNF is crucial for synaptic plasticity, influencing the strength and efficacy of connections between neurons, which is vital for learning and memory processes.

Customer Reviews (3)

Write a review
Reviews
12/31/2022

    The BDNF protein is carefully characterized, and its functional properties are well-documented.

    04/08/2021

      With its high purity and bioactivity, BDNF protein ensures reliable and consistent results in a wide range of experimental applications.

      11/27/2017

        The BDNF protein is of exceptional quality and is perfectly suited to meet the experimental needs of researchers.

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