BDNF
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Official Full Name
brain-derived neurotrophic factor
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Overview
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimers and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009] -
Synonyms
BDNF; brain-derived neurotrophic factor; ANON2; BULN2; abrineurin; neurotrophin;
- Recombinant Proteins
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Transfected Stable Cell Lines
- Cell & Tissue Lysates
- Cattle
- Chicken
- Dog
- Guinea pig
- Horse
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Zebrafish
- CHO
- CHO-K1
- E. coli
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His(C
- ter)
- Myc
- His|GST
- SUMO
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BDNF Related Articles
- BDNF Related Gene Family
- BDNF Related Research Area
BDNF involved in several pathways and played different roles in them. We selected most pathways BDNF participated on our site, such as MAPK signaling pathway, cAMP signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | FGF6;ELK1;FASLG;CACNB3A;MRAS;PPP3CCB;FGF13B;PRKCG;CACNA1SA |
cAMP signaling pathway | ARAP3;GNAI3;GRIA4;ATP1B4;AKT1;MAPK3;CNGA1;RAC2;NPY1R |
Neurotrophin signaling pathway | MAPK3;SH2B2;PLCG2;CAMK2B;ARHGDIG;BCL2;ZFP110;NGFR;MAP3K5 |
Huntingtons disease | DNAH14;SOD1;NDUFA1;TBPL1;NDUFV2;NDUFS5;DNAH5;POLR2J2;DNAI1 |
Cocaine addiction | PDYN;CREB3L1;SLC18A2;DRD1;ATF6B;GNAS;CREB3;GNAI1;DDC |
Alcoholism | HIST1H2BH;H2AFZ;HIST1H2AM;HIST1H2AB;PPP1CC;NTRK2;HIST1H2AC;HIST2H2BB;GRIN2B |
BDNF has several biochemical functions, for example, growth factor activity, neurotrophin TRKB receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BDNF itself. We selected most functions BDNF had, and list some proteins which have the same functions with BDNF. You can find most of the proteins on our site.
Function | Related Protein |
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growth factor activity | TGFB2;NTF3;PPBP;FGF1B;F2;EGF;VEGFC;PDGFAB;BMP2B |
neurotrophin TRKB receptor binding | BDNF;EFNA5 |
BDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of BDNF.
NTF3; SORCS2; NTF4; JUNB; INPP5K; AGO3; F11R
- Q&As
- Reviews
Q&As (5)
Ask a questionBDNF levels can be measured through blood tests or cerebrospinal fluid analysis, providing insights into the protein's concentration in the body.
BDNF deficiency has been linked to conditions such as Alzheimer's disease, Parkinson's disease, and depression.
While there are no direct BDNF medications, certain drugs and treatments aim to enhance BDNF levels indirectly, offering potential therapeutic benefits.
Physical exercise has been shown to increase BDNF production, suggesting that exercise could be used as a non-pharmacological intervention to support neurological health.
BDNF is crucial for synaptic plasticity, influencing the strength and efficacy of connections between neurons, which is vital for learning and memory processes.
Customer Reviews (3)
Write a reviewThe BDNF protein is carefully characterized, and its functional properties are well-documented.
With its high purity and bioactivity, BDNF protein ensures reliable and consistent results in a wide range of experimental applications.
The BDNF protein is of exceptional quality and is perfectly suited to meet the experimental needs of researchers.
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