BDNF
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Official Full Name
brain-derived neurotrophic factor
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Overview
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimers and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009] -
Synonyms
BDNF; brain-derived neurotrophic factor; ANON2; BULN2; abrineurin; neurotrophin;
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What is bdnf protein?
BDNF belongs to the neurotrophin family of growth factors, which also includes NGF, NT-3 and NT-4/5.
It works by binding to and activating tyrosine kinase receptors, namely TrkB (tropomyosin receptor kinase B) receptors on neurons.
Binding of BDNF to TrkB triggers intracellular signaling cascades that influence neuronal development, plasticity and repair processes.
BDNF is important for the growth, differentiation, maintenance and survival of certain neuronal populations, both during development and in adulthood.
What is the function of bdnf protein?
Neuronal survival and growth - BDNF promotes the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses during development.
Synaptic plasticity - It helps strengthen synaptic connections between neurons by inducing activity-dependent synaptic plasticity. This is important for processes like learning and memory.
Dendrite and spine development - BDNF stimulates dendritic growth, arborization and spinogenesis, thereby shaping the architecture of neuronal circuits.
Neurogenesis - It plays a role in the ongoing generation of new neurons from neural stem cells in the hippocampus and other brain regions in adulthood.
Bdnf related signaling pathway
Binding of BDNF to its high affinity receptor TrkB leads to auto-phosphorylation of Tyrosine residues in the intracellular domain of TrkB.
This allows the recruitment and binding of adapter proteins like Shc and Frs2.
The adapter proteins trigger the downstream activation of the Ras-Raf-MEK-ERK cascade. MEK phosphorylates and activates ERK1/2.
Phosphorylated ERK1/2 translocates to the nucleus and activates transcription factors like CREB, ELK-1 and others.
This induces the expression of several immediate early genes (IEGs) as well as proteins involved in neuronal survival, synaptic plasticity and resilience.
BDNF Related Diseases
- Neurodegenerative diseases: Reduced BDNF levels are implicated in Alzheimer's, Parkinson's, Huntington's disease.
- Depression: Many depression medications increase BDNF, suggesting its role. Genetic variations affecting BDNF signaling are depression risk factors.
- Anxiety disorders: Altered BDNF signaling has been linked to anxiety, PTSD and obsessive-compulsive disorder.
- Schizophrenia: Decreased BDNF plays a role, impacting synaptic plasticity and psychosis severity.
- Epilepsy: Genetic and acquired forms of epilepsy involve BDNF dysregulation, influencing excitability.
- Neurodegenerative disease treatment - BDNF supplementation may help treat Alzheimer's, Parkinson's, Huntington's by promoting neuronal survival.
- Spinal cord injury repair - BDNF enhances axon regeneration and functional recovery after injury. Gene therapy approaches utilize this.
- Depression/anxiety treatment - Existing antidepressants work partly by boosting BDNF. Direct administration may help treatment-resistant cases.
- Neurodegenerative disease treatment - BDNF supplementation may help treat Alzheimer's, Parkinson's, Huntington's by promoting neuronal survival.
- Spinal cord injury repair - BDNF enhances axon regeneration and functional recovery after injury. Gene therapy approaches utilize this.
- Depression/anxiety treatment - Existing antidepressants work partly by boosting BDNF. Direct administration may help treatment-resistant cases.
High Purity
Fig1. SDS-PAGE (Cat. No.: BDNF-243H)
(Huimin Zhang, 2018)
Fig2. Endogenous gene expressions of human BDNF-AS were tested by qPCR in eight cervical cancer cell lines, SiHa, DoTc2-4510, Ca-Ski, HeLa, HeLa/S3, C-4I, C-4II and C-33-A, and compared to BDNF-AS gene expression in a non-cancer HPV-16 E6/E7 transformed cervical epithelial cell line.
(Svitlana V. Bach, 2023)
Fig3. Western blot for BDNF protein after CRISPRa targeting of Bdnf I, Bdnf IV, and Bdnf I & IV transcripts revealed a significant increase in BDNF protein levels in all conditions as compared to the non-targeting lacZ control (n = 7, one-way ANOVA, F(3, 24) = 6.696, p = 0.0019; Dunnett's multiple comparisons test).
BDNF involved in several pathways and played different roles in them. We selected most pathways BDNF participated on our site, such as MAPK signaling pathway, cAMP signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | IL1B;PAK1;CACNG8;TGFB3;RAP1AA;CACNB3A;PDGFA;CACNG6A;PPP3R1 |
| cAMP signaling pathway | PIK3CG;MLLT4;F2R;EP300;CNGA2;PPARA;RAC2;HTR1B;PRKACA |
| Neurotrophin signaling pathway | MAPK8;Fasl;ARHGDIG;MAPK9;CALM1;PIK3R5;KRAS;PTPN11;MAPKAPK2 |
| Huntingtons disease | NDUFB9;DNAH5;NDUFA8;PPARGC1A;NDUFS3;DNALI1;GRIN1;COX8A;POLR2J3 |
| Cocaine addiction | CREB3L2;GRIA2;GRIN1;CREB3L4;GRIN3A;PRKACG;GRIN2B;FOSB;GPSM1 |
| Alcoholism | GM14479;CALM4;GNG10;HDAC10;H2AFB2;CREB3L3;PPP1CB;SLC29A1;SLC18A1 |
BDNF has several biochemical functions, for example, growth factor activity, neurotrophin TRKB receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BDNF itself. We selected most functions BDNF had, and list some proteins which have the same functions with BDNF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | SPAW;JAG1;GDNF;OSGIN1;FGF16;VHL;FGF17;NRG1;MSTNA |
| neurotrophin TRKB receptor binding | EFNA5;BDNF |
BDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of BDNF.
NTF3; SORCS2; NTF4; JUNB; INPP5K; AGO3; F11R
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Customer Reviews (3)
Write a reviewThe BDNF protein is carefully characterized, and its functional properties are well-documented.
With its high purity and bioactivity, BDNF protein ensures reliable and consistent results in a wide range of experimental applications.
The BDNF protein is of exceptional quality and is perfectly suited to meet the experimental needs of researchers.
Q&As (5)
Ask a questionBDNF levels can be measured through blood tests or cerebrospinal fluid analysis, providing insights into the protein's concentration in the body.
BDNF deficiency has been linked to conditions such as Alzheimer's disease, Parkinson's disease, and depression.
While there are no direct BDNF medications, certain drugs and treatments aim to enhance BDNF levels indirectly, offering potential therapeutic benefits.
Physical exercise has been shown to increase BDNF production, suggesting that exercise could be used as a non-pharmacological intervention to support neurological health.
BDNF is crucial for synaptic plasticity, influencing the strength and efficacy of connections between neurons, which is vital for learning and memory processes.
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