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Official Full Name brain-derived neurotrophic factor
Background The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimers and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
Synonyms BDNF; brain-derived neurotrophic factor; ANON2; BULN2; abrineurin; neurotrophin;
    • Species :
    • Chicken
    • Dog
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BDNF-007H Recombinant Human BDNF Protein E. coli
    Human BDNF-2555H Recombinant Human BDNF protein, His-tagged E.coli His
    Human BDNF-2585H Recombinant Human BDNF protein, His-SUMO-tagged E.coli His-SUMO
    Human BDNF-2586H Recombinant Human BDNF protein, GST-tagged E.coli GST
    Human BDNF-003H Recombinant Human BDNF Human N/A
    Human BDNF-022H Recombinant Human Brain Derived Neurotrophic Factor E.coli N/A
    Human BDNF-10202H Recombinant Human BDNF, GST-tagged E.coli GST
    Human BDNF-113HG GMP Recombinant Human BDNF Protein Insect Cell N/A
    Human BDNF-155H Human Brain-derived Neurotrophic Factor (rDNA derived) Reference standard E.coli N/A
    Human BDNF-187H Recombinant Human BDNF Protein, GST-tagged Wheat Germ GST
    Human BDNF-188H Recombinant Human BDNF Protein, GST-tagged Wheat Germ GST
    Human BDNF-22H Recombinant Human BDNF Protein, His-tagged HEK293 His
    Human BDNF-231H Recombinant Human Brain-derived Neurotrophic Factor, His-tagged E.coli His
    Human BDNF-243H Recombinant Human BDNF protein, His-tagged E.coli His
    Human BDNF-2466H Recombinant Human BDNF Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BDNF-258H Recombinant Human BDNF protein E.coli N/A
    Human BDNF-3171H Recombinant Human BDNF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BDNF-334H Recombinant Human Brain-derived Neurotrophic Factor Sf21 Insect Cell N/A
    Human BDNF-491H Recombinant Human BDNF protein, His-tagged HEK293F His
    Human BDNF-549H Recombinant Human BDNF protein, GST-tagged E.coli GST
    Human BDNF-72H Recombinant Human BDNF protein CHO N/A
    Mouse BDNF-001MCL Recombinant Mouse BDNF cell lysate CHO N/A
    Mouse Bdnf-550M Recombinant Mouse Bdnf protein, His & GST-tagged E.coli His/GST
    Mouse Bdnf-703M Recombinant Mouse Bdnf Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Bdnf-736M Recombinant Mouse Bdnf protein E.coli N/A
    Mouse Bdnf-7392M Recombinant Mouse Bdnf, None tagged CHO N/A
    Mouse BDNF-9843M Recombinant Mouse BDNF protein, His-tagged HEK293 His
    Rat Bdnf-552R Recombinant Rat Bdnf protein, His-tagged E.coli His
    Rat BDNF-966R Recombinant Rat BDNF Protein Mammalian Cell His
    Dog BDNF-545D Recombinant Dog BDNF protein, His-tagged E.coli His
    Chicken BDNF-3252C Recombinant Chicken BDNF Mammalian Cell His
    Chicken BDNF-547C Recombinant Chicken BDNF protein, His-tagged E.coli His
    Rabbit BDNF-553R Recombinant Rabbit BDNF protein, His-tagged E.coli His
    Zebrafish BDNF-9136Z Recombinant Zebrafish BDNF Mammalian Cell His
    Horse BDNF-546H Recombinant Horse BDNF protein, His-tagged E.coli His
    Guinea pig Bdnf-548G Recombinant Guinea pig Bdnf protein, His & GST-tagged E.coli His/GST
    Pig BDNF-551P Recombinant Pig BDNF protein, His-tagged E.coli His

    BDNF involved in several pathways and played different roles in them. We selected most pathways BDNF participated on our site, such as MAPK signaling pathway, cAMP signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF22; PRKCA; PDGFAA; PDGFRA; CDC42L2; PRKCBB; FGF13; RPS6KA5; PPP3R1B; MAPK12B
    cAMP signaling pathway NPR1; FXYD1; GABBR2; MAP2K1; RAC1; HTR1B; ATP1B2; MAP2K2; PDE3B; RAC3
    Neurotrophin signaling pathway MAP3K3; ARHGDIB; SHC1; ARHGDIA; NGF; RHOA; SH2B3; RAPGEF1; NRAS; IKBKB
    Huntingtons disease POLR2I; SDHA; PLCB4; ATP5G1; TBP; NDUFA5; COX7A2; COX7C; ATP5O; BBC3
    Cocaine addiction SLC6A3; GPSM1; CREB3L2; ATF4; GNAI2; RELA; CREB3L1; GNAI1; PRKACG; CREB5
    Alcoholism BDNF; TH; GM14477; HIST1H4F; CAMK4; HIST1H3E; CREB3L4; HIST1H4E; ATF6B; HIST1H2BN

    BDNF has several biochemical functions, for example, growth factor activity, neurotrophin TRKB receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BDNF itself. We selected most functions BDNF had, and list some proteins which have the same functions with BDNF. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity FGF13; NTF4; FGF10B; MSTN; INHBA; PPBP; PDGFC; GRN; THPO; BMP15
    neurotrophin TRKB receptor binding EFNA5; BDNF

    BDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of BDNF.


    Nam, JH; Leem, E; et al. Induction of GDNF and BDNF by hRheb(S16H) Transduction of SNpc Neurons: Neuroprotective Mechanisms of hRheb(S16H) in a Model of Parkinson's Disease. MOLECULAR NEUROBIOLOGY 51:487-499(2015).
    Jeon, MT; Nam, JH; et al. In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production. MOLECULAR THERAPY 23:445-455(2015).

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