Human Clusterin
Cat.No. : | CLU-3661H |
Product Overview : | Native protein purified from human plasma. |
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Cat. No. : | CLU-3661H |
Description : | Clusterin is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene. |
Source : | native |
Species : | Human |
Form : | Filtered (0,4 μm) and lyophilized from PBS, pH 7.5. |
Research topic : | Others; Renal disease; Sepsis |
Purity : | >95% |
Reconstitution : | Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. |
Applications : | ELISA; Western blotting |
Quality Control Test : | BCA to determine quantity of the protein; SDS-PAGE to determine purity of the protein |
Storage : | Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C. |
Publication : |
Clusterin and complement activation in exfoliation glaucoma (2014)
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Gene Name : | CLU clusterin [ Homo sapiens ] |
Official Symbol : | CLU |
Synonyms : | CLU; clusterin; CLI; AAG4; APOJ; KUB1; SGP2; SGP-2; SP-40; TRPM2; TRPM-2; MGC24903; apo-J; NA1/NA2; apolipoprotein J; OTTHUMP00000128311; OTTHUMP00000225247; OTTHUMP00000225248; OTTHUMP00000225249; ku70-binding protein 1; sulfated glycoprotein 2; aging-associated protein 4; complement lysis inhibitor; complement cytolysis inhibitor; complement-associated protein SP-40,40; testosterone-repressed prostate message 2 |
Gene ID : | 1191 |
mRNA Refseq : | NM_203339 |
Protein Refseq : | NP_976084 |
MIM : | 185430 |
UniProt ID : | P10909 |
Chromosome Location : | 8p21-p12 |
Pathway : | Formation of Platelet plug; Hemostasis; Platelet Activation; Platelet degranulation; Response to elevated platelet cytosolic Ca2+; Validated targets of C-MYC transcriptional repression |
Function : | NOT ATPase activity; misfolded protein binding; ubiquitin protein ligase binding; ubiquitin protein ligase binding |
Products Types
◆ Recombinant Protein | ||
CLU-13H | Recombinant human CLU protein (23-449aa), N-6×His-tagged | +Inquiry |
CLU-1526H | Recombinant Human CLU Protein, GST-tagged | +Inquiry |
Clu-039M | Recombinant Mouse Clu Protein, His-tagged | +Inquiry |
Clu-040M | Recombinant Mouse Clu Protein, MYC/DDK-tagged | +Inquiry |
CLU-746R | Recombinant Rhesus Macaque CLU Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
CLU-19H | Native Human Clusterin Protein | +Inquiry |
CLU-67H | Native Human Clusterin | +Inquiry |
◆ Lysates | ||
CLU-2195MCL | Recombinant Mouse CLU cell lysate | +Inquiry |
CLU-2198HCL | Recombinant Human CLU cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.
CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.
CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.
CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.
CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.
Customer Reviews (3)
Write a reviewImpressed with the quality control. This product is a gem in our lab experiments.
Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.
Our lab manager introduced us to this product, and we're never going back. Essential for our studies.
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