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Recombinant Human S100A8, His-tagged

Cat.No. : S100A8-3732H
Product Overview : Total 103 AA. MW: 12.08 kDa (calculated). N-Terminal His-tag, 10 extra AA (highlighted).
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Cat. No. : S100A8-3732H
Description : Protein S100-A8 is a protein that in humans is encoded by the S100A8 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
Source : E. coli
Species : Human
Form : Filtered (0,4 μm) and lyophilized in 0.5 mg/mL in 20mM TRIS, 100mM NaCl, pH 7.5
Reconstitution : Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Applications : Western blotting
Quality Control Test : BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein
Sequences of amino acids : MKHHHHHHAS MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE
Storage : Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Gene Name : S100A8 S100 calcium binding protein A8 [ Homo sapiens ]
Official Symbol : S100A8
Synonyms : S100A8; S100 calcium binding protein A8; P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG; protein S100-A8; MRP-8; calgranulin A; OTTHUMP00000015329; cystic fibrosis antigen; calprotectin L1L subunit; urinary stone protein band A; leukocyte L1 complex light chain; migration inhibitory factor-related protein 8; S100 calcium-binding protein A8 (calgranulin A); S100 calcium binding protein A8 (calgranulin A)
Gene ID : 6279
mRNA Refseq : NM_002964
Protein Refseq : NP_002955
MIM : 123885
UniProt ID : P05109
Chromosome Location : 1q12-q22
Function : calcium ion binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do alterations in S100A8 expression impact cellular stress responses and aging? 03/03/2022

Changes in S100A8 expression impact cellular stress responses, with implications for aging and age-related diseases.

How does S100A8 contribute to the pathogenesis of cancer, especially in terms of tumor growth and metastasis? 12/12/2021

S100A8 contributes to cancer development, influencing tumor cell proliferation and metastatic potential.

What is the impact of S100A8 on wound healing and tissue repair mechanisms? 03/02/2021

S100A8 is involved in wound healing, affecting tissue repair and regeneration.

How does S100A8 interact with calcium ions and what are the implications for inflammatory processes? 01/18/2021

S100A8 binds calcium ions, modulating inflammatory processes and cytokine production.

How does S100A8 influence the development and progression of cardiovascular diseases? 11/01/2019

S100A8 affects cardiovascular disease development, impacting inflammation and vascular integrity.

What role does S100A8 play in the immune response, particularly in autoimmune diseases? 09/22/2019

S100A8 plays a significant role in the immune response, impacting the pathogenesis of autoimmune diseases.

What are the effects of S100A8 on skin homeostasis and the development of skin disorders? 10/06/2018

S100A8 influences skin health, playing a role in maintaining skin barrier function and in skin disorders.

Customer Reviews (3)

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Reviews
02/01/2022

    Dependable protein quantification, ensures experimental accuracy.

    10/29/2020

      Consistent western blot results, a lab essential.

      03/12/2020

        Expert protein engineering support, essential for our projects.

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