"CDK2" Related Products

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Recombinant Human CDK2, His-tagged

Cat. No.: CDK2-797H
Product Overview: Recombinant human CDK2 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography (1-298aa).
Description: CDK2, also known as cyclin-depentent kinase 2, is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and is essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by protein phosphorylation.
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
Molecular Weight: 35.0 kDa (306aa), confirmed by MALDI-TOF
Purity: > 95% by SDS - PAGE
Concentration: 0.5 mg/ml (determined by Bradford assay)
Sequences of amino acids: MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRLLE HHHHHH
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Cell cycle; Pathways in cancer ; Progesterone-mediated oocyte maturation; Prostate cancer; Small cell lung cancer; p53 signaling pathway; DNA Replication; Cell Cycle, Mitotic; Cell Cycle Checkpoints
Gene Name: CDK2 cyclin-dependent kinase 2 [ Homo sapiens ]
Official Symbol: CDK2
Synonyms: CDK2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; EC 2.7.11.22; cell devision protein kinase 2; CCNA2; p33(CDK2); cyclin A2; CCN1; CCNA; Cyclin-A; Cyclin-A2
Gene ID: 1017
mRNA Refseq: NM_001798
Protein Refseq: NP_001789
MIM: 116953
UniProt ID: P24941
Chromosome Location: 12q13
Function: ATP binding; cyclin-dependent protein kinase activity; histone kinase activity; identical protein binding; nucleotide binding; transferase activity; protein binding; protein kinase activity

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