"MAP2K4" Related Products


Recombinant Human Mitogen-Activated Protein Kinase kinase 4, His-tagged

Cat. No. : MAP2K4-597H
Product Overview : Recombinant human MAP2K4 protein, was expressed as 6 his-tagged fusion protein by E. coli and purified by Ni-sepharose.
Description : MAP2K4 encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
Source : Human
Host : E. coli
Expression Vector : PET28a
Form : The puri?ed protein was resolved in 1 M PBS (58 mM Na2HPO4,17 mM NaH2PO4, 68 mM NaCl, pH 8.) added with 300 mM Imidazole and 0.7% Sarcosyl, 15% glycerol.
Buffer : PBS based buffer
Sequence : 50-399 amino acids
Molecular Mass : 44 kDa
Storage : The protein is stored in PBS bu?er at -20°C. Repeated freeze-thaw cycles should be avoided.
Rendering based on PDB 3ALN. :

Gene Name : MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens ]
Official Symbol : MAP2K4
Synonyms : MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; SEK1; SAPK/ERK kinase 1; PRKMK4; MKK4; MEK4; MAPKK4; MAPK/ERK kinase 4; MAP kinase kinase 4; JNKK1; JNKK; JNK-activating kinase 1; JNK-activated kinase 1; EC; dual specificity mitogen-activated protein kinase kinase 4; Dual specificity mitogen-activated protein kinase kinase 4; c-Jun N-terminal kinase kinase 1
Gene ID : 6416
mRNA Refseq : NM_003010
Protein Refseq : NP_003001
MIM : 601335
UniProt ID : P45985
Chromosome Location : 17p11.2
Pathway : Activated TLR4 signalling; Apoptosis; CD40/CD40L signaling; CDC42 signaling events; Cellular roles of Anthrax toxin; Ceramide signaling pathway; Chagas disease (American trypanosomiasis); Cytokine Signaling in Immune system; Ephrin B reverse signaling; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; ErbB1 downstream signaling; FAS pathway and Stress induction of HSP regulation; Fc epsilon RI signaling pathway; GnRH signaling pathway
Function : ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity

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