"ERBB4" Related Products


Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged

Cat. No. : ERBB4-1126H
Product Overview : Recombinant human ERBB4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : ERBB4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin.
Biological Activity : 137 pmol/µg×min
Molecular Weight : 102,062 Da
Source : Sf9 insect cells
Species : Human
Appearance : Liquid
Storage : 50 mMTris-HCl, pH 8.0;100 mMNaCl, 5 mM DTT, 15 mM reducedglutathione, 20% glycerol.
Pathways : Calcium signaling pathway; Endocytosis; ErbB signaling pathway
PDB rendering based on 2ahx. :

Gene Name : ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [ Homo sapiens ]
Official Symbol : ERBB4
Synonyms : ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4; Receptor tyrosine-protein kinase erbB-4; HER4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; EC; MGC138404; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; OTTHUMP00000163968; OTTHUMP00000206623; OTTHUMP00000209432
Gene ID : 2066
mRNA Refseq : NM_001042599
Protein Refseq : NP_001036064
MIM : 600543
UniProt ID : Q15303
Chromosome Location : 2q33.3-q34
Function : ATP binding; nucleotide binding; protein binding; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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