Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, GST-tagged
Cat.No. : | LYN-1127H |
Product Overview : | Recombinant human LYN was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | LYN-1127H |
Description : | LYN is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck andthe v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization analysisshowed that a 3.2-kilobase LYN mRNA was expressed in a variety of tissues of the human fetus. LYNis expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that LYN isphysically associated with membrane-bound IgM, and participates in antigen-mediated signaltransduction. Crosslinking of membrane-bound IgM with antibody induces rapid increase in activitiesof LYN and Lyn-associated phosphatidylinositol 3-kinase. Crosslinking of B-cell antigen receptor alsoinduces association of LYN with an 85-kDa noncatalytic subunit of phosphatidylinositol 3-kinase. Thus,LYN is functionally associated with membrane-bound IgM and participates in B-cell antigen receptormediatedsignaling. |
Biological Activity : | 180 nmol phosphate incorporated into Poly(Glu-Tyr) per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay). |
Molecular Weight : | 85.0 kDa |
Source : | Sf9 insect cells |
Species : | Human |
Form : | Recombinant protein in storage buffer (50 mMTris-HCl, pH 7.5, 150 mMNaCl, 0.25 mM DTT, 0.1 mMEGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol). |
Appearance : | Liquid |
Purity : | >98% by SDS-PAGE and HPLC analyses |
Storage : | Store product frozen at or below -70ºC. Stable for 1 year at -70ºC as undiluted stock. Aliquot to avoidrepeated thawing and freezing. |
Pathways : | B cell receptor signaling pathway; Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Hemostasis; Signaling in Immune system; Fc epsilon RI signaling pathway; IL-2 Signaling Pathway |
Gene Name : | LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens ] |
Official Symbol : | LYN |
Synonyms : | LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; JTK8; FLJ26625; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog; EC 2.7.10.2; OTTHUMP00000226393; OTTHUMP00000226394 |
Gene ID : | 4067 |
mRNA Refseq : | NM_001111097 |
Protein Refseq : | NP_001104567 |
MIM : | 165120 |
UniProt ID : | P07948 |
Chromosome Location : | 8q13 |
Function : | ATP binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; receptor signaling protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding |
Products Types
◆ Recombinant Protein | ||
LYN-12H | Recombinant Human LYN Protein (Full Length), N-FLAG tagged | +Inquiry |
LYN-4557H | Active Recombinant Human LYN Protein, GST/His-tagged | +Inquiry |
LYN-3170R | Recombinant Rat LYN Protein, His (Fc)-Avi-tagged | +Inquiry |
LYN-4556H | Recombinant Human LYN Protein, GST-tagged | +Inquiry |
LYN-514H | Recombinant Human LYN Protein, His-tagged | +Inquiry |
◆ Lysates | ||
LYN-656HCL | Recombinant Human LYN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket