"LYN" Related Products


Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, GST-tagged

Cat. No. : LYN-1127H
Product Overview : Recombinant human LYN was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : LYN is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck andthe v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization analysisshowed that a 3.2-kilobase LYN mRNA was expressed in a variety of tissues of the human fetus. LYNis expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that LYN isphysically associated with membrane-bound IgM, and participates in antigen-mediated signaltransduction. Crosslinking of membrane-bound IgM with antibody induces rapid increase in activitiesof LYN and Lyn-associated phosphatidylinositol 3-kinase. Crosslinking of B-cell antigen receptor alsoinduces association of LYN with an 85-kDa noncatalytic subunit of phosphatidylinositol 3-kinase. Thus,LYN is functionally associated with membrane-bound IgM and participates in B-cell antigen receptormediatedsignaling.
Biological Activity : 180 nmol phosphate incorporated into Poly(Glu-Tyr) per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay).
Molecular Weight : 85.0 kDa
Source : Sf9 insect cells
Species : Human
Form : Recombinant protein in storage buffer (50 mMTris-HCl, pH 7.5, 150 mMNaCl, 0.25 mM DTT, 0.1 mMEGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Appearance : Liquid
Purity : >98% by SDS-PAGE and HPLC analyses
Storage : Store product frozen at or below -70ºC. Stable for 1 year at -70ºC as undiluted stock. Aliquot to avoidrepeated thawing and freezing.
Pathways : B cell receptor signaling pathway; Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Hemostasis; Signaling in Immune system; Fc epsilon RI signaling pathway; IL-2 Signaling Pathway
PDB rendering based on 1wa7. :

Gene Name : LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens ]
Official Symbol : LYN
Synonyms : LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; JTK8; FLJ26625; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog; EC; OTTHUMP00000226393; OTTHUMP00000226394
Gene ID : 4067
mRNA Refseq : NM_001111097
Protein Refseq : NP_001104567
MIM : 165120
UniProt ID : P07948
Chromosome Location : 8q13
Function : ATP binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; receptor signaling protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding

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