Recombinant Human GDF11, His-tagged GDF11-38H

Recombinant Human GDF11, His-tagged


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Recombinant Human GDF11, His-tagged

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Cat.No. : GDF11-38H
Product Overview : Recombinant human BMP-11 is N-terminus His-tagged protein with a molecular weight of 32.6 kDa (for homodimeric) and 16.2 (for monomeric) consisting of 136 amino acid polypeptide chains.
Description : The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized protein. Lyophilized from 10 mM Sodium Citrate, pH 3.5.
Bio-activity : The protein is biologically active as determined by its ability to induce alkaline phosphatase production by C2C12 cells. The ED50 is in the range of 0.4-4 µg/ml.
Molecular Mass : 32.6 kDa
Endotoxin : <0.1 ng/μg
Purity : ≥98% by SDS-PAGE and HPLC
Storage : The lyophilized protein is best-stored desiccated below 0°C. Reconstituted BMP-11 should be stored in working aliquots at -20°C.
Reconstitution : Reconstitute to a concentration of 0.1-1.0 mg/ml in water containing BSA (50 μg BSA per 1 μg of protein). This solution can then be diluted into other aqueous buffers.
Gene Name : GDF11 growth differentiation factor 11 [ Homo sapiens (human) ]
Official Symbol : GDF11
Synonyms : GDF11; growth differentiation factor 11; BMP11; BMP-11; bone morphogenetic protein 11; GDF-11; growth/differentiation factor 11
Gene ID : 10220
mRNA Refseq : NM_005811
Protein Refseq : NP_005802
MIM : 603936
UniProt ID : O95390
Chromosome Location : 12q13.13
Function : cytokine activity; growth factor activity; transforming growth factor beta receptor binding

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