"CASP1" Related Products

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Recombinant Human Caspase 1, Apoptosis-Related Cysteine Peptidase (interleukin 1, beta, convertase), His-tagged

Cat. No.: CASP1-1639H
Product Overview: Recombinant active human CASP1 containing N-term His-tag was expressed in E. coli.
Description: CASP1 (also know as ICE) is a prototypical member of the caspase-family of cysteine proteases. CASP1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kD) and small (10 kD) subunits. The active CASP1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of CASP1 activation and the role of CASP1 in apoptosis are poorly understood.
Biological Activity: > 5000 units/mg
Molecular Weight: large (20 kD) and small (10 kD) subunitsk
Source: E. coli
Species: Human
Form: Lyophilized powder.
Appearance: Lyophilized powder
Reconstitution: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Storage: The lyophilized CASP1 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease.
Pathways: Amyotrophic lateral sclerosis (ALS); Androgen Receptor Signaling Pathway; Apoptosis; Caspase cascade in apoptosis; Cellular roles of Anthrax toxin; Cytokine Signaling in Immune system; Cytosolic DNA-sensing pathway; Direct p53 effectors; IFN-gamma pathway; IL1-mediated signaling events; Immune System; Inflammasomes; Influenza A; Innate Immunity Signaling; Interleukin-1 processing
Gene Name: CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) [ Homo sapiens ]
Official Symbol: CASP1
Synonyms: CASP1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); ICE; P45; IL1BC; caspase-1; IL-1BC; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1-B converting enzyme; Caspase-1; CASP-1; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; EC 3.4.22.36; OTTHUMP00000045728; OTTHUMP00000232029; OTTHUMP00000232030; OTTHUMP00000232031; OTTHUMP00000232032; OTTHUMP00000232033; OTTHUMP00000232034; OTTHUMP00000232036
Gene ID: 834
mRNA Refseq: NM_033292
Protein Refseq: NP_150634
MIM: 147678
UniProt ID: P29466
Chromosome Location: 11q23
Function: cysteine-type endopeptidase activity; caspase activator activity; peptidase activity; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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