Recombinant Human Beta-Site APP-Cleaving Enzyme 1
Cat.No. : | BACE1-1661H |
Product Overview : | Recombinant human BACE1 is Generation of the 40 or 42 amino acid-long amyloid-β peptides. |
- Specification
- Gene Information
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Cat. No. : | BACE1-1661H |
Description : | BACE1 (β-site of APP cleaving enzyme) or memapsin-2 is an aspartic-acid protease important in the pathogenesis of Alzheimer"s disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein, contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. |
Biological Activity : | BACE1 is biologically active as determined using our β-Secretase Activity Assay Kit. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from 100 mM Na2B4O7, 200 mM NaCl, pH 8.5. |
Appearance : | Lyophilized protein |
Reconstitution : | Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml. |
Purity : | ≥95% by SDS-PAGE |
Storage : | The lyophilized protein is best-stored desiccated below 0°C. Reconstituted BACE-1 should be aliquoted and stored at -70°C. |
Gene Name : | BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ] |
Official Symbol : | BACE1 |
Synonyms : | BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; FLJ90568; KIAA1149; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; OTTHUMP00000218630; OTTHUMP00000218631; OTTHUMP00000218632; OTTHUMP00000218633; OTTHUMP00000218635; OTTHUMP00000218636; OTTHUMP00000235006; OTTHUMP00000235007; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme |
Gene ID : | 23621 |
mRNA Refseq : | NM_001207048 |
Protein Refseq : | NP_001193977 |
MIM : | 604252 |
UniProt ID : | P56817 |
Chromosome Location : | 11q23-q24 |
Pathway : | Alzheimer"s disease |
Function : | aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity |
Products Types
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BACE1-2200H | Recombinant Human BACE1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
BACE1-3006HCL | Recombinant Human BACE1 cell lysate | +Inquiry |
BACE1-3077MCL | Recombinant Mouse BACE1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.
BACE1 is implicated in Alzheimer's disease as it initiates the cleavage of APP, leading to the formation of beta-amyloid plaques, a hallmark of the disease.
BACE1 inhibitors may slow down or prevent the accumulation of beta-amyloid plaques, potentially delaying the progression of Alzheimer's disease.
Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.
Yes, BACE1 inhibitors are being explored as potential therapeutic agents for Alzheimer's disease to reduce the production of beta-amyloid peptides.
Customer Reviews (3)
Write a reviewSuch support ensures researchers have access to reliable tools and expertise, facilitating their investigations into the functions, mechanisms, and disease relevance of BACE1 protein.
A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.
Using BACE1 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.
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