"BACE1" Related Products

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Recombinant Human Beta-Site APP-Cleaving Enzyme 1

Cat. No.: BACE1-1661H
Product Overview: Recombinant human BACE1 is Generation of the 40 or 42 amino acid-long amyloid-β peptides.
Description: BACE1 (β-site of APP cleaving enzyme) or memapsin-2 is an aspartic-acid protease important in the pathogenesis of Alzheimer"s disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein, contains two active site aspartate residues in its extracellular protein domain and may function as a dimer.
Biological Activity: BACE1 is biologically active as determined using our β-Secretase Activity Assay Kit.
Source: E. coli
Species: Human
Form: Lyophilized from 100 mM Na2B4O7, 200 mM NaCl, pH 8.5.
Appearance: Lyophilized protein
Reconstitution: Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml.
Purity: ≥95% by SDS-PAGE
Storage: The lyophilized protein is best-stored desiccated below 0°C. Reconstituted BACE-1 should be aliquoted and stored at -70°C.
Gene Name: BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ]
Official Symbol: BACE1
Synonyms: BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; FLJ90568; KIAA1149; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; OTTHUMP00000218630; OTTHUMP00000218631; OTTHUMP00000218632; OTTHUMP00000218633; OTTHUMP00000218635; OTTHUMP00000218636; OTTHUMP00000235006; OTTHUMP00000235007; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme
Gene ID: 23621
mRNA Refseq: NM_001207048
Protein Refseq: NP_001193977
MIM: 604252
UniProt ID: P56817
Chromosome Location: 11q23-q24
Pathway: Alzheimer"s disease
Function: aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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