Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Beta-Site APP-Cleaving Enzyme 1

Cat.No. : BACE1-1661H
Product Overview : Recombinant human BACE1 is Generation of the 40 or 42 amino acid-long amyloid-β peptides.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : BACE1-1661H
Description : BACE1 (β-site of APP cleaving enzyme) or memapsin-2 is an aspartic-acid protease important in the pathogenesis of Alzheimer"s disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein, contains two active site aspartate residues in its extracellular protein domain and may function as a dimer.
Biological Activity : BACE1 is biologically active as determined using our β-Secretase Activity Assay Kit.
Source : E. coli
Species : Human
Form : Lyophilized from 100 mM Na2B4O7, 200 mM NaCl, pH 8.5.
Appearance : Lyophilized protein
Reconstitution : Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml.
Purity : ≥95% by SDS-PAGE
Storage : The lyophilized protein is best-stored desiccated below 0°C. Reconstituted BACE-1 should be aliquoted and stored at -70°C.
Gene Name : BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ]
Official Symbol : BACE1
Synonyms : BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; FLJ90568; KIAA1149; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; OTTHUMP00000218630; OTTHUMP00000218631; OTTHUMP00000218632; OTTHUMP00000218633; OTTHUMP00000218635; OTTHUMP00000218636; OTTHUMP00000235006; OTTHUMP00000235007; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme
Gene ID : 23621
mRNA Refseq : NM_001207048
Protein Refseq : NP_001193977
MIM : 604252
UniProt ID : P56817
Chromosome Location : 11q23-q24
Pathway : Alzheimer"s disease
Function : aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any potential side effects associated with BACE1 inhibition? 08/20/2021

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

How is BACE1 linked to Alzheimer's disease? 01/05/2020

BACE1 is implicated in Alzheimer's disease as it initiates the cleavage of APP, leading to the formation of beta-amyloid plaques, a hallmark of the disease.

How can BACE1 inhibitors potentially benefit Alzheimer's patients? 08/11/2018

BACE1 inhibitors may slow down or prevent the accumulation of beta-amyloid plaques, potentially delaying the progression of Alzheimer's disease.

Are there any ongoing clinical trials involving BACE1 inhibitors? 09/22/2017

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

Are there clinical applications of BACE1 inhibitors? 08/07/2016

Yes, BACE1 inhibitors are being explored as potential therapeutic agents for Alzheimer's disease to reduce the production of beta-amyloid peptides.

Customer Reviews (3)

Write a review
Reviews
07/27/2020

    Such support ensures researchers have access to reliable tools and expertise, facilitating their investigations into the functions, mechanisms, and disease relevance of BACE1 protein.

    12/23/2019

      A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.

      09/30/2019

        Using BACE1 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.

        Ask a Question for All BACE1 Products

        Required fields are marked with *

        My Review for All BACE1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends