"MMP8" Related Products


Recombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase)

Cat. No.: MMP8-1656H
Product Overview: The action of endoglycosidase on the latent 58-kDa form produces 42/40-kDa species. This indicates that MMP8 is an N-linked, complex glycoprotein that appears to be glycosylated at multiple sites.
Description: Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP8 present in the starting material can either be latent or active, or have an app. relative molecular mass of 75-kDa and/or 58-kDa. The rather complex pattern of activation of the latent 58-kDa and 75-kDa species by trypsin, organomercurials and oxidants has been investigated. MMP8 was shown to preferentially hydrolyze type I over type II, and type III collagens in solution and to be a glycoprotein that contains complex N-linked oligosaccharides leading to multiple forms of MMP8 in SDS-PAGE.
Molecular Weight: 40/42 kDa
Source: Human neutrophil granulocytes (Buffy Coat)
Species: Human
Form: Liquid, in 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl2; 1 μM ZnCl2; 0.05% Brij 35; 0,05% NaN3.
Appearance: Liquid
Storage: MMP8 is very stable if aliquoted and stored (prevents auto-activation) at -70°C. Repeated freezing and thawing should be avoided.
Pathways: Matrix Metalloproteinases
Gene Name: MMP8 matrix metallopeptidase 8 (neutrophil collagenase) [ Homo sapiens ]
Official Symbol: MMP8
Synonyms: MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMNL collagenase; OTTHUMP00000236265; OTTHUMP00000236267; matrix metalloproteinase-8; Matrix metalloproteinase-8; EC; EC 3.4.24
Gene ID: 4317
mRNA Refseq: NM_002424
Protein Refseq: NP_002415
MIM: 120355
UniProt ID: P22894
Chromosome Location: 11q22.3
Function: calcium ion binding; metalloendopeptidase activity; peptidase activity; serine-type endopeptidase activity; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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