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Recombinant Human Bone Morphogenetic Protein Receptor, Type IB, GST-tagged

Cat. No.: BMPR1B-992H
Product Overview: Recombinant human BMPR1B (149-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: BMPR1B (also known as ALK6) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. ALK6 is mainly involved in the endochondral bone formation and embryogenesis. ALK6 expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients. BMPR1B receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation.
Applications: Kinase Assay; Western Blot
Molecular Weight: 68 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Specific Activity: 23 nmol/min/mg
Purity: > 85 %
Concentration: 0.1 ug/ul
Sequences: 149-end
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP; Ovarian Infertility Genes
Gene Name: BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]
Official Symbol: BMPR1B
Synonyms: BMPR1B; bone morphogenetic protein receptor, type IB; ALK6; ALK-6; CDw293; bone morphogenetic protein receptor type-1B; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase; Bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; EC 2.7.11.30; OTTHUMP00000161621; OTTHUMP00000161622; OTTHUMP00000219359; OTTHUMP00000219880; OTTHUMP00000219882
Gene ID: 658
mRNA Refseq: NM_001203
Protein Refseq: NP_001194
MIM: 603248
UniProt ID: O00238
Chromosome Location: 4q23-q24
Function: ATP binding; SMAD binding; activin receptor activity, type II; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity

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