"ELP3" Related Products

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Recombinant Human Elongation Protein 3 Homolog (S. Cerevisiae), GST-tagged

Cat. No.: ELP3-1583H
Product Overview: Recombinant full-length human ELP3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: ELP3 is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons. The knockdown of ELP3 by antisense morpholinos in zebrafish embryos resulted in dose-dependent shortening and abnormal branching of motor neurons with no concomitant morphologic abnormalities. ELP3 knockdown also impairs paternal DNA demethylation as indicated by reporter binding, immunostaining, and bisulfite sequencing.
Applications: Western Blot
Molecular Weight: 86 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Purity: > 75 %
Concentration: 0.1 ug/ul
Sequences: Full length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: ELP3 elongation protein 3 homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol: ELP3
Synonyms: ELP3; elongation protein 3 homolog (S. cerevisiae); KAT9; FLJ10422; elongator complex protein 3; hELP3; OTTHUMP00000128319; OTTHUMP00000225327; OTTHUMP00000225330; EC 2.3.1.48
Gene ID: 55140
mRNA Refseq: NM_018091
Protein Refseq: NP_060561
MIM: 612722
UniProt ID: Q9H9T3
Chromosome Location: 8p21.1
Function: contributes_to DNA binding; N-acetyltransferase activity; histone acetyltransferase activity; iron-sulfur cluster binding; metal ion binding; phosphorylase kinase regulator activity; protein binding; transferase activity, transferring acyl groups

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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