"GRK1" Related Products


Recombinant Human G Protein-Coupled Receptor Kinase 1, GST-tagged

Cat. No. : GRK1-1018H
Product Overview : Full-length recombinant human GRK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases. GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
Applications : Kinase Assay; Western Blot
Molecular Weight : 95 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity : >95%
Concentration : 0.1 ug/ul
Specific Activity : 4.3 nmol/min/mg
Sequences : Full length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Chemokine signaling pathway; Endocytosis; Visual signal transduction
Gene Name : GRK1 G protein-coupled receptor kinase 1 [ Homo sapiens ]
Official Symbol : GRK1
Synonyms : GRK1; G protein-coupled receptor kinase 1; RK; RHOK; GPRK1; rhodopsin kinase
Gene ID : 6011
mRNA Refseq : NM_002929
Protein Refseq : NP_002920
MIM : 180381
UniProt ID : Q15835
Chromosome Location : 13q34
Function : G-protein coupled receptor kinase activity; nucleotide binding; ATP binding; protein kinase activity; rhodopsin kinase activity; signal transducer activity

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