"HDAC4" Related Products


Recombinant Human Distone Deacetylase 4, GST-tagged

Cat. No.: HDAC4-1592H
Product Overview: Recombinant human HDAC4 (612-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: HDAC4 or Histone Deacetylase 4 belongs to class II of the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity.
Applications: HDAC Assay; Western Blot
Molecular Weight: 77 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity: >95%
Concentration: 0.1 ug/ul
Specific Activity: 60 RLU/min/ng
Sequences: 612-end
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Cell cycle; Endochondral Ossification; MicroRNAs in cardiomyocyte hypertrophy; Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class II; Signaling events mediated by HDAC Class III; Sumoylation by RanBP2 regulates transcriptional repression
Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens ]
Official Symbol: HDAC4
Synonyms: HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; KIAA0288; histone deacetylase 4; OTTHUMP00000164483; histone deacetylase A
Gene ID: 9759
mRNA Refseq: NM_006037
Protein Refseq: NP_006028
MIM: 605314
UniProt ID: P56524
Chromosome Location: 2q37
Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; histone deacetylase binding; protein binding; protein deacetylase activity; repressing transcription factor binding; contributes_to sequence-specific DNA binding; contributes_to transcription regulatory region DNA binding; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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