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Recombinant Human heat shock 70kDa protein 1A, GST-tagged

Cat.No. : HSPA1A-4850H
Product Overview : Recombinant full-length human HSPA1A was expressed in E. coli cells using an N-terminal GST tag.
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Cat. No. : HSPA1A-4850H
Description : HSPA1A is a member of the heat shock protein family and is synthesized by cells of many organisms in response to stress. HSPA1A is found mostly but not exclusively in the nucleus of unstressed cells. For several hours after a short heat shock, however, it is strongly concentrated in nucleoli. Nucleoli are transiently damaged by such a heat shock: their morphology changes and assembly and export of ribosomes is blocked for several hours.
Applications : ATPase Assay; Western Blot
Molecular Weight : 96 kDa
Expression System : E. coli
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity : >90%
Concentration : 0.2 ug/ul
Sequences : Full-length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Antigen processing and presentation; Antigen processing and presentation; Apoptosis Modulation by HSPA1A; Direct p53 effectors; Endocytosis; Influenza A; MAPK signaling pathway; Measles; Prion diseases; Protein processing in endoplasmic reticulum; Spliceosome; Toxoplasmosis; FOXM1 transcription factor network
Gene Name : HSPA1A heat shock 70kDa protein 1A [ Homo sapiens ]
Official Symbol : HSPA1A
Synonyms : HSPA1A; heat shock 70kDa protein 1A; HSP72; HSPA1; HSPA1AI; HSPA1B; HSPA1A-1; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127; HSPA1A-1A; heat shock 70 kDa protein 1A/1B; HSPA1A-1/HSPA1A-2; HSPA1A.1/HSPA1A.2; OTTHUMP00000029287; heat shock 70kD protein 1A; heat shock-induced protein; heat shock 70 kDa protein 1/2; dnaK-type molecular chaperone HSPA1A-1
Gene ID : 3303
mRNA Refseq : NM_005345
Protein Refseq : NP_005336
MIM : 140550
UniProt ID : P08107
Chromosome Location : 6p21

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How is HSPA1A associated with other proteins or diseases? 06/20/2022

HSPA1A has multiple associations with other proteins and diseases. For example, it may interact with the p53 protein to affect the occurrence and progression of tumors, and may also be associated with neurodegenerative diseases and be involved in the pathogenesis of diseases such as Alzheimer's disease.

What is the role of HSPA1A in stressful conditions? 05/24/2022

HSPA1A can protect cells from damage through synergistic effects with other molecular chaperones such as HSP70 and HSP40 under stressful conditions. In addition, it can also be involved in the regulation of apoptosis.

Does HSPA1A have therapeutic potential? 03/24/2022

Yes, HSPA1A has therapeutic potential. In tumor therapy, drug suppression or gene therapy against HSPA1A may become a new way to treat tumors. At the same time, inhibitors against HSPA1A are also being developed.

What are the health effects of aberrant expression of HSPA1A? 06/28/2021

Aberrant expression of HSPA1A may be associated with a variety of diseases, especially cancer, neurodegenerative diseases, etc. For example, in tumors such as lung, breast, and colon cancer, HSPA1A expression levels may be abnormally elevated.

How is the level of HSPA1A detected? 03/18/2020

Levels of HSPA1A can be detected by methods such as immunohistochemistry, western blotting, and real-time PCR, which can assess the amount of HSPA1A in tissues and cells.

How is HSPA1A involved in the proper folding and transport of proteins? 02/18/2020

This protein can bind to unfolded proteins to form multimeric complexes that facilitate proper folding and transport of proteins. In addition, it can also work synergistically with other molecular chaperones such as HSP70 and HSP40 to participate in the correct folding and transport of proteins.

Customer Reviews (3)

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Reviews
05/11/2022

    Using HSPA1A experiments can obtain consistent results and reduce the uncertainty of experiments.

    01/26/2022

      HSPA1A has good stability and is suitable for long-term storage and use.

      01/10/2021

        HSPA1A can effectively simulate the function of the target protein in vitro.

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