Recombinant Human heat shock 70kDa protein 1A, GST-tagged
Cat.No. : | HSPA1A-4850H |
Product Overview : | Recombinant full-length human HSPA1A was expressed in E. coli cells using an N-terminal GST tag. |
- Specification
- Gene Information
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Cat. No. : | HSPA1A-4850H |
Description : | HSPA1A is a member of the heat shock protein family and is synthesized by cells of many organisms in response to stress. HSPA1A is found mostly but not exclusively in the nucleus of unstressed cells. For several hours after a short heat shock, however, it is strongly concentrated in nucleoli. Nucleoli are transiently damaged by such a heat shock: their morphology changes and assembly and export of ribosomes is blocked for several hours. |
Applications : | ATPase Assay; Western Blot |
Molecular Weight : | 96 kDa |
Expression System : | E. coli |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Purity : | >90% |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Antigen processing and presentation; Antigen processing and presentation; Apoptosis Modulation by HSPA1A; Direct p53 effectors; Endocytosis; Influenza A; MAPK signaling pathway; Measles; Prion diseases; Protein processing in endoplasmic reticulum; Spliceosome; Toxoplasmosis; FOXM1 transcription factor network |
Gene Name : | HSPA1A heat shock 70kDa protein 1A [ Homo sapiens ] |
Official Symbol : | HSPA1A |
Synonyms : | HSPA1A; heat shock 70kDa protein 1A; HSP72; HSPA1; HSPA1AI; HSPA1B; HSPA1A-1; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127; HSPA1A-1A; heat shock 70 kDa protein 1A/1B; HSPA1A-1/HSPA1A-2; HSPA1A.1/HSPA1A.2; OTTHUMP00000029287; heat shock 70kD protein 1A; heat shock-induced protein; heat shock 70 kDa protein 1/2; dnaK-type molecular chaperone HSPA1A-1 |
Gene ID : | 3303 |
mRNA Refseq : | NM_005345 |
Protein Refseq : | NP_005336 |
MIM : | 140550 |
UniProt ID : | P08107 |
Chromosome Location : | 6p21 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionHSPA1A has multiple associations with other proteins and diseases. For example, it may interact with the p53 protein to affect the occurrence and progression of tumors, and may also be associated with neurodegenerative diseases and be involved in the pathogenesis of diseases such as Alzheimer's disease.
HSPA1A can protect cells from damage through synergistic effects with other molecular chaperones such as HSP70 and HSP40 under stressful conditions. In addition, it can also be involved in the regulation of apoptosis.
Yes, HSPA1A has therapeutic potential. In tumor therapy, drug suppression or gene therapy against HSPA1A may become a new way to treat tumors. At the same time, inhibitors against HSPA1A are also being developed.
Aberrant expression of HSPA1A may be associated with a variety of diseases, especially cancer, neurodegenerative diseases, etc. For example, in tumors such as lung, breast, and colon cancer, HSPA1A expression levels may be abnormally elevated.
Levels of HSPA1A can be detected by methods such as immunohistochemistry, western blotting, and real-time PCR, which can assess the amount of HSPA1A in tissues and cells.
This protein can bind to unfolded proteins to form multimeric complexes that facilitate proper folding and transport of proteins. In addition, it can also work synergistically with other molecular chaperones such as HSP70 and HSP40 to participate in the correct folding and transport of proteins.
Customer Reviews (3)
Write a reviewUsing HSPA1A experiments can obtain consistent results and reduce the uncertainty of experiments.
HSPA1A has good stability and is suitable for long-term storage and use.
HSPA1A can effectively simulate the function of the target protein in vitro.
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