Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged
Cat.No. : | MAP2K1-1035H |
Product Overview : | Recombinant full-length human MAP2K1 was expressed in Sf9 insect cells using an N-terminal His tag. |
- Specification
- Gene Information
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Cat. No. : | MAP2K1-1035H |
Description : | MAP2K1 is a protein serine/threonine kinase that is an upstream activator of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of ERKs by MAP2K1 involves phosphorylation of both tyrosine and threonine residues. MAP2K1, like the ERKs is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. MEK plays an important role in the growth and survival of cancer cells. In hepatocellular carcinoma, MEK activity is frequently elevated and inhibitors of MEK activity may be an effective treatment for this disease. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 47 kDa |
Expression System : | Sf9 insect cells using baculovirus. |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol. |
Purity : | > 90% |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Dorso-ventral axis formation; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prion diseases; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton |
Gene Name : | MAP2K1 mitogen-activated protein kinase kinase 1 [ Homo sapiens ] |
Official Symbol : | MAP2K1 |
Synonyms : | MAP2K1; mitogen-activated protein kinase kinase 1; MEK1; MKK1; MAPKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); EC 2.7.12.2; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1 |
Gene ID : | 5604 |
mRNA Refseq : | NM_002755 |
Protein Refseq : | NP_002746 |
MIM : | 176872 |
UniProt ID : | Q02750 |
Chromosome Location : | 15q22.1-q22.33 |
Function : | ATP binding; MAP kinase kinase activity; Ras GTPase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; receptor signaling protein tyrosine phosphatase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
MAP2K1-3215R | Recombinant Rat MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K1-3430H | Recombinant Human MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K1-1310M | Recombinant Mouse MAP2K1 protein(Met1-Ile393), His&GST-tagged | +Inquiry |
MAP2K1-2483R | Recombinant Rhesus Macaque MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Map2k1-3920M | Recombinant Mouse Map2k1 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
MAP2K1-001MCL | Recombinant Mouse MAP2K1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1614 | MEK1 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, there are clinical trials exploring the efficacy and safety of MAP2K1 inhibitors in various cancers and other diseases.
Some diagnostic tests may analyze MAP2K1 mutations, especially in the context of cancer, to inform treatment decisions.
MAP2K1 mutations can serve as biomarkers in cancer diagnostics, aiding in the identification and classification of tumors.
MAP2K1 mutations can be associated with resistance to certain cancer therapies, making it important to understand its role in treatment response.
Yes, MAP2K1 inhibitors are being explored as targeted therapies in cancer treatment, aiming to block the abnormal signaling associated with MAP2K1 mutations.
Customer Reviews (3)
Write a reviewThe unmatched performance of the MAP2K1 protein in both ELISA assays and protein electron microscopy structure analysis showcases its versatility and reliability in various experimental settings.
The MAP2K1 protein finds extensive utility in protein electron microscopy structure analysis.
With its exceptional specificity and sensitivity, it enables precise and reliable detection of target molecules, making it a valuable tool in the field of diagnostic and research applications.
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