"MAPK3" Related Products

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Recombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged

Cat. No.: MAPK3-1049H
Product Overview: Recombinant full-length human MAPK3 was expressed in E.coli using an N-terminal GST tag.
Description: MAPK3 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of MAPK3 requires both tyrosine and threonine phosphorylation that is mediated by MEK. MAPK3 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated MAPK3 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta).
Applications: Kinase Assay, Western Blot
Molecular Weight: 70 kDa
Expression System: E. coli
Species: Human
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity: > 95 %
Concentration: 0.1 ug/ul
Sequences: Full-length
Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Acute myeloid leukemia; Adherens junction; Alzheimer"s disease; Alzheimer"s disease; B cell receptor signaling pathway; Bladder cancer; Chronic myeloid leukemia; Chemokine signaling pathway; Colorectal cancer; Dorso-ventral axis formation; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term potentiation; Long-term depression; MAPK signaling pathway; Melanogenesis
Gene Name: MAPK3 mitogen-activated protein kinase 3 [ Homo sapiens ]
Official Symbol: MAPK3
Synonyms: MAPK3; mitogen-activated protein kinase 3; ERK1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; MGC20180; EC 2.7.11.24; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; Microtubule-associated protein 2 kinas; OTTHUMP00000174538; OTTHUMP00000174540; Microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3
Gene ID: 5595
mRNA Refseq: NM_002746
Protein Refseq: NP_002737
MIM: 601795
UniProt ID: P27361
Chromosome Location: 16p11.2
Function: ATP binding; MAP kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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