"PIP5K1A" Related Products

Recombinant Human Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, GST-tagged

Cat. No.: PIP5K1A-1082H
Product Overview: Recombinant full-length human PIP5K1A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: PIP5K1A or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4, 5-bisphosphate. PIP5K1A is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells. Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through "frizzled" and "dishevelled", the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP.
Applications: Kinase Assay; Western Blot
Molecular Weight: 86 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50mM Tris-HCL, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF,0 25% glycerol.
Specific Activity: 1310 nmol/min/mg
Purity: > 90 %
Concentration: 0.1 ug/ul
Sequences: Full length
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: 3-phosphoinositide biosynthesis; Arf1 pathway; Arf6 downstream pathway; B Cell Receptor Signaling Pathway; D-myo-inositol (1,4,5)-trisphosphate biosynthesis; E-cadherin signaling in keratinocytes; Endocytosis; Fc gamma R-mediated phagocytosis; Inositol phosphate metabolism; Metabolic pathways; Osteopontin-mediated events; Phosphatidylinositol signaling system; RAC1 signaling pathway; Regulation of actin cytoskeleton; RhoA signaling pathway
Gene Name: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [ Homo sapiens ]
Official Symbol: PIP5K1A
Synonyms: PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; PIP5KIalpha; PIP5K1-alpha; OTTHUMP00000014289; OTTHUMP00000014290; OTTHUMP00000014291; OTTHUMP00000196331; OTTHUMP00000235065; ptdIns(4)P-5-kinase 1 alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
Gene ID: 8394
mRNA Refseq: NM_001135636
Protein Refseq: NP_001129108
MIM: 603275
UniProt ID: Q99755
Chromosome Location: 1q21.3
Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; kinase activity; kinase binding; nucleotide binding; protein binding; transferase activity

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