"PRMT1" Related Products

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Recombinant Human Protein Arginine Methyltransferase 1, GST-tagged

Cat. No.: PRMT1-1616H
Product Overview: Recombinant full-length human PRMT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: PRMT1 is a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4. PRMT1 specifically methylates arginine-3 of histone H4 in vitro and in vivo. Methylation of arg3 by PRMT1 facilitates subsequent acetylation of histone H4 tails by p300. PRMT1 performs methylation of arg31 of STAT1 and this is required for transcription induced by IFN-alpha/IFN-beta. Arginine methylation of STAT1 is an additional posttranslational modification regulating transcription factor function, and alteration of arginine methylation might be responsible for the lack of interferon responsiveness observed in many malignancies.
Applications: Western Blot
Molecular Weight: 67 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol, 0.1 mM EDTA.
Purity: > 90 %
Concentration: 0.1 ug/ul
Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Androgen Receptor Signaling Pathway; Direct p53 effectors; Energy Metabolism; Tryptophan metabolism; mRNA processing
Gene Name: PRMT1 protein arginine methyltransferase 1 [ Homo sapiens ]
Official Symbol: PRMT1
Synonyms: PRMT1; protein arginine methyltransferase 1; ANM1; HCP1; IR1B4; HRMT1L2;protein arginine N-methyltransferase 1; OTTHUMP00000236172; OTTHUMP00000236176; OTTHUMP00000236178; OTTHUMP00000236179; HMT1 hnRNP methyltransferase-like 2; interferon receptor 1-bound protein 4; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; NP_938074.2; EC 2.1.1.125
Gene ID: 3276
mRNA Refseq: NM_198318
Protein Refseq: NP_938074
MIM: 602950
UniProt ID: Q8WUW5
Chromosome Location: 19q13.3
Function: N-methyltransferase activity; core promoter proximal region DNA binding; enzyme binding; histone methyltransferase activity; histone methyltransferase activity (H4-R3 specific); methyltransferase activity; protein binding; transferase activity

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