"PTEN" Related Products

Recombinant Human Phosphatase And Tensin Homolog, GST-tagged

Cat. No. : PTEN-1619H
Product Overview : Full-length recombinant human PTEN was expressed in E. coli cells using an N-terminal GST tag.
Description : PTEN is a tumor suppressor that is frequently mutated in a large number of cancers. PTEN has phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.
Applications : Phosphatase Assay; Western Blot
Molecular Weight : 80 kDa
Expression System : E. coli
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Specific Activity : 435 nmol/min/mg
Purity : > 85 %
Concentration : 0.1 ug/ul
Sequences : Full length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Endometrial cancer; Focal adhesion; Glioma; Inositol phosphate metabolism; Melanoma; Pathways in cancer; Phosphatidylinositol signaling; Prostate cancer; Small cell lung cancer; Tight junction; p53 signaling pathway; Signaling in Immune system; Signalling by NGF; PIP3 activates AKT signaling
Crystallographicstructure of human PTEN. The N-terminal phosphatase domain is colored bluewhile the C-terminal C2 domain is colored red. :

Gene Name : PTEN phosphatase and tensin homolog [ Homo sapiens ]
Official Symbol : PTEN
Synonyms : PTEN; phosphatase and tensin homolog; BZS; DEC; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; MGC11227; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; OTTHUMP00000020032; phosphatase and tensin-like protein; mutated in multiple advanced cancers 1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog
Gene ID : 5728
mRNA Refseq : NM_000314
Protein Refseq : NP_000305
MIM : 601728
UniProt ID : P60484
Chromosome Location : 10q23
Function : PDZ domain binding; hydrolase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; magnesium ion binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; platelet-derived growth factor receptor binding; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; enzyme binding

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