Recombinant Human Ras Homolog Gene Family, Member C, His-tagged


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Recombinant Human Ras Homolog Gene Family, Member C, His-tagged

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Cat. No. : RHOC-1628H
Product Overview : Recombinant full length human RHOC was expressed in E. coli cells using an N-terminal His tag.
Description : RHOC is member of the Rho family of small GTPases which promote reorganization of the actin cytoskeleton during cell morphogenesis and motility and regulate cell shape, attachment and motility. Active RHOC signals to its downstream effector ROCK which phosphorylates and activates LIM kinase that in turn phosphorylates cofilin inhibiting its actin-depolymerizing activity. Overexpression of RhoC is associated with tumor cell proliferation and metastasis while dominant-negative RHOC inhibits metastasis.
Applications : Kinase Assay; Western Blot
Molecular Weight : 23 kDa
Expression System : E. coli
Species : Human
Form : Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol.
Purity : > 75 %
Concentration : 0.2 ug/ul
Sequences : Full length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Axon guidance; G alpha (12/13) signalling events; GPCR downstream signaling; Rho GTPase cycle; Sema4D in semaphorin signaling; Sema4D induced cell migration and growth-cone collapse; Semaphorin interactions; Signaling by GPCR; Signaling by Rho GTPases; Signaling events mediated by PRL
PDBrendering based on 1a2b. :

Gene Name : RHOC ras homolog gene family, member C [ Homo sapiens ]
Official Symbol : RHOC
Synonyms : RHOC; ras homolog gene family, member C; H9; ARH9; ARHC; RHOH9; MGC1448; MGC61427; rho-related GTP-binding protein RhoC; rhoC GTPase; oncogene RHO H9; rho cDNA clone 9; OTTHUMP00000013675; OTTHUMP00000013676; OTTHUMP00000013802; OTTHUMP00000013803; OTTHUMP00000013804; OTTHUMP00000013805; OTTHUMP00000013806; OTTHUMP00000013807; OTTHUMP00000013809; OTTHUMP00000229713; OTTHUMP00000229714; RAS-related homolog 9; small GTP binding protein RhoC; Rho-related GTP-binding protein RhoC; Rho cDNA clone 9
Gene ID : 389
mRNA Refseq : NM_001042678
Protein Refseq : NP_001036143
MIM : 165380
UniProt ID : P08134
Chromosome Location : 1p13.1
Function : GTP binding; GTPase activity; protein domain specific binding; nucleotide binding; signal transducer activity

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