Recombinant Human Signal Transducer And Activator Of Transcription 1, 91kDa, GST-tagged

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Recombinant Human Signal Transducer And Activator Of Transcription 1, 91kDa, GST-tagged

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Cat. No. : STAT1-4885H
Product Overview : Recombinant full-length human STAT1 beta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : STAT1 is a member of the signal transducers and activators of transcription (STAT) family of proteins that carry out a dual function: signal transduction and activation of transcription. STAT1 transcription factor is specific for the IFN pathway and plays a central role in mediating many, if not all, IFN-dependent biological responses. Presence of STAT1 leads to an efficient antiviral response when cells were infected with virus suggesting that a STAT-dependent pathway is activated following virus infection by endogenously produced IFN. Virus-induced STAT protein translocation from the cytoplasmic compartment can be detected within 3 h of infection.
Applications : Kinase Assay; Western Blot
Molecular Weight : 118 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Purity : > 90 %
Concentration : 0.2 ug/ul
Sequences : Full-length
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Chemokine signaling pathway; Jak-STAT signaling pathway; Pancreatic cancer; Toll-like receptor signaling pathway; Signaling by PDGF
Gene Name : STAT1 signal transducer and activator of transcription 1, 91kDa [ Homo sapiens ]
Official Symbol : STAT1
Synonyms : STAT1; signal transducer and activator of transcription 1, 91kDa; ISGF-3; STAT91; DKFZp686B04100; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription-1; transcription factor ISGF-3 components p91/p84
Gene ID : 6772
mRNA Refseq : NM_007315
Protein Refseq : NP_009330
MIM : 600555
UniProt ID : P42224
Chromosome Location : 2q32.2
Function : calcium ion binding; matopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity; protein binding; sequence-specific DNA binding; signal transducer activity; transcription factor activity

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