"TEC" Related Products


Recombinant Human Tec Protein Tyrosine Kinase, GST-tagged

Cat. No.: TEC-1111H
Product Overview: Full-length recombinant human TEC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: TEC is a member of the Tec family of non-receptor protein-tyrosine kinases that are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. TEC is an integral component of T cell signaling and has a distinct role in T cell activation. Defects in TEC may be associated with myelodysplastic syndrome. TEC plays a crucial role in regulating FGF2 secretion under various physiological conditions and it inhibits CD25 expression in human T-lymphocyte.
Applications: Kinase Assay; Western Blot
Molecular Weight: 103 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Specific Activity: 10 nmol/min/mg
Purity: > 75 %
Concentration: 0.1 ug/ul
Sequences: Full-length
Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: T cell receptor signaling pathway
Gene Name: TEC tec protein tyrosine kinase [ Homo sapiens ]
Official Symbol: TEC
Synonyms: TEC; tec protein tyrosine kinase; PSCTK4; MGC126760; MGC126762; tyrosine-protein kinase Tec; EC
Gene ID: 7006
mRNA Refseq: NM_003215
Protein Refseq: NP_003206
MIM: 600583
UniProt ID: P42680
Chromosome Location: 4p12
Function: ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity

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