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Recombinant Human Tousled-Like Kinase 1, GST-tagged

Cat.No. : TLK1-1112H
Product Overview : Recombinant full-length human TLK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Cat. No. : TLK1-1112H
Description : TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1.
Applications : Kinase Assay; Western Blot
Molecular Weight : 135 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Specific Activity : 6.2 nmol/min/mg
Purity : > 90 %
Concentration : 0.1 ug/ul
Sequences : Full-length
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : TLK1 tousled-like kinase 1 [ Homo sapiens ]
Official Symbol : TLK1
Synonyms : TLK1; tousled-like kinase 1; KIAA0137; PKU-beta; Serine/threonine-protein kinase tousled-like 1; EC=2.7.11.1; Tousled-like kinase 1; serine threonine protein kinase; SNARE protein kinase SNAK; EC 2.7.11; EC 2.7.11.1; PKU-BETA; OTTHUMP00000205035; OTTHUMP00000205036; OTTHUMP00000205037; OTTHUMP00000205038; OTTHUMP00000205039; OTTHUMP00000225037; OTTHUMP00000163076; OTTHUMP00000163077
Gene ID : 9874
mRNA Refseq : NM_012290
Protein Refseq : NP_036422
MIM : 608438
UniProt ID : Q9UKI8
Chromosome Location : 2q31.1
Function : ATP binding; protein serine/ threonine kinase activity; nucleotide binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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