Recombinant Human Tousled-Like Kinase 1, GST-tagged
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Cat. No. : | TLK1-1112H |
Product Overview : | Recombinant full-length human TLK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
Description : | TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 135 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol. |
Specific Activity : | 6.2 nmol/min/mg |
Purity : | > 90 % |
Concentration : | 0.1 ug/ul |
Sequences : | Full-lengt h |
Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | TLK1 tousled-like kinase 1 [ Homo sapiens ] |
Official Symbol : | TLK1 |
Synonyms : | TLK1; tousled-like kinase 1; KIAA0137; PKU-beta; Serine/threonine-protein kinase tousled-like 1; EC=2.7.11.1; Tousled-like kinase 1; serine threonine protein kinase; SNARE protein kinase SNAK; EC 2.7.11; EC 2.7.11.1; PKU-BETA; OTTHUMP00000205035; OTTHUMP00000205036; OTTHUMP00000205037; OTTHUMP00000205038; OTTHUMP00000205039; OTTHUMP00000225037; OTTHUMP00000163076; OTTHUMP00000163077 |
Gene ID : | 9874 |
mRNA Refseq : | NM_012290 |
Protein Refseq : | NP_036422 |
MIM : | 608438 |
UniProt ID : | Q9UKI8 |
Chromosome Location : | 2q31.1 |
Function : | ATP binding; protein serine/ threonine kinase activity; nucleotide binding |
◆ Recombinant Protein
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Tlk1-6449M | Recombinant Mouse Tlk1 Protein, Myc/DDK-tagged | +Inquiry |
TLK1-901H | Recombinant Human TLK1, His & GST tagged | +Inquiry |
TLK1-3252H | Recombinant Human TLK1, GST-tagged | +Inquiry |
TLK1-1497H | Recombinant Human TLK1 (Active), GST-tagged | +Inquiry |
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◆ Lysates
TLK1-589HCL | Recombinant Human TLK1 cell lysate | +Inquiry |
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