Recombinant Human Tousled-Like Kinase 1, GST-tagged TLK1-1112H

Cat. No.:	TLK1-1112H
Product Overview:	Recombinant full-length human TLK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description:	TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1.
Applications:	Kinase Assay; Western Blot
Molecular Weight:	135 kDa
Expression System:	Sf9 insect cells using baculovirus
Species:	Human
Form:	Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Specific Activity:	6.2 nmol/min/mg
Purity:	> 90 %
Concentration:	0.1 ug/ul
Sequences:	Full-length
Storage:	Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

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Gene Name:	TLK1 tousled-like kinase 1 [ Homo sapiens ]
Official Symbol:	TLK1
Synonyms:	TLK1; tousled-like kinase 1; KIAA0137; PKU-beta; Serine/threonine-protein kinase tousled-like 1; EC=2.7.11.1; Tousled-like kinase 1; serine threonine protein kinase; SNARE protein kinase SNAK; EC 2.7.11; EC 2.7.11.1; PKU-BETA; OTTHUMP00000205035; OTTHUMP00000205036; OTTHUMP00000205037; OTTHUMP00000205038; OTTHUMP00000205039; OTTHUMP00000225037; OTTHUMP00000163076; OTTHUMP00000163077
Gene ID:	9874
mRNA Refseq:	NM_012290
Protein Refseq:	NP_036422
MIM:	608438
UniProt ID:	Q9UKI8
Chromosome Location:	2q31.1
Function:	ATP binding; protein serine/ threonine kinase activity; nucleotide binding