"TP63" Related Products


Recombinant Human Tumor Protein P63, GST-tagged

Cat. No. : TP63-327H
Product Overview : Full-length recombinant human TP63 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Description : TP63 is the primordial member of the p53 family that acts in a conserved process of monitoring the integrity of the female germline, whereas the functions of p53 are restricted to vertebrate somatic cells for tumor suppression. TP63 protein plays an important role in the development and maintenance of stratified epithelial tissues. p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis. Mutations in TP63 are associated with ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3) and split-hand/foot malformation 4 (SHFM4).
Applications : Kinase Assay; Western Blot
Molecular Weight : 92 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50mM Tris-HCI, pH 7.5, 150mM NaCl, 10 mMgultathione, 0.1 mMEDTA, 0.25 mM DTT, 0.1mMPMSF 25% glycerol.
Purity : >90%
Concentration : 0.2ug/ul
Sequences : Full-length
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Apoptosis; Direct p53 effectors; TP53 network
Gene Name : TP63 tumor protein p63 [ Homo sapiens ]
Official Symbol : TP63
Synonyms : TP63; tumor protein p63; AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B); CUSP; OTTHUMP00000209732;OTTHUMP00000209733;OTTHUMP00000209734; OTTHUMP00000209735; OTTHUMP00000209737; OTTHUMP00000209738; OTTHUMP00000209739; OTTHUMP00000209740; OTTHUMP00000209741; OTTHUMP00000209742; OTTHUMP00000209743; OTTHUMP00000209744; transformation-related protein 63; tumor protein p53-competing protein; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; tumor protein p63 deltaN isoform delta; tumor protein p53-like, tumor protein p73-like; P63; P73H; P73L
Gene ID : 8626
mRNA Refseq : NM_001114980
Protein Refseq : NP_001108452
MIM : 603273
UniProt ID : Q9H3D4
Chromosome Location : 3q28
Function : DNA binding; chromatin binding; damaged DNA binding; double-stranded DNA binding; identical protein binding; metal ion binding; p53 binding; protein binding; protein domain specific binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity

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