"TUBB" Related Products


Recombinant Human TUBB, GST-tagged

Cat.No.: TUBB-4892H
Product Overview: Recombinant full-length human TUBB1 was expressed in E. coli cells using an N-terminal GST tag.
Description: TUBB1 or tubulin-beta 1 protein is a major constituent of microtubules. TUBB1 interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. Previous work suggested that the "microtubule binding domain" of tau (composed of three or four imperfect 18-amino acid repeats, separated by 13- or 14-amino acid inter-repeat regions) can bind to the C-terminal ends of both alpha and beta tubulin monomers. Studies revealed that TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded that TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance.
Source: E.coli
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~76 kDa
Purity: The purity was determined to be >85% by densitometry.
Applications: Kinase Assay; Western Blot
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.2 ug/ul
Gene Name: TUBB tubulin, beta class I [ Homo sapiens (human) ]
Official Symbol: TUBB
Synonyms: TUBB; M40; TUBB1; TUBB5; OK/SW-cl.56; tubulin, beta class I; tubulin beta chain; beta1-tubulin; beta 5-tubulin; beta-4 tubulin; beta Ib tubulin; class I beta-tubulin; tubulin beta-1 chain; tubulin beta-5 chain; tubulin beta polypeptide; tubulin, beta polypeptide
Gene ID: 203068
mRNA Refseq: NM_178014
Protein Refseq: NP_821133
MIM: 191130
UniProt ID: P07437
Chromosome Location: 6p21.33
Pathway: Centrosome maturation; G2/M Transition; Loss of Nlp from mitotic centrosomes
Function: GTP binding; GTPase activity; MHC class I protein binding

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