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Recombinant Human CD40 Molecule, TNF Receptor Superfamily Member 5

Cat. No.: CD40-4980H
Product Overview: Recombinant human CD40 was expressed in E.coli and purified by using conventional chromatography techniques.
Description: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L.
Source: Human
Host: E.coli
Form: Sterile filtered through a 0.2 um filter. Lyophilized from 10 mM Na3PO4, pH 7.5. Reconstitute in 5-10 mM Na3PO4, pH 7.5 to a concentration of 0.1-1.0 mg/ml.
Purity: >98% pure by SDS PAGE and HPLC
Sequence: Region of CD40 protein corresponding to amino acids MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL.
Molecular Mass: 16.3 kDa
Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens ]
Official Symbol: CD40
Synonyms: CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; MGC9013; TNFRSF5; CD40 antigen; CD40 type II isoform; CD40L receptor; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule; tumor necrosis factor receptor superfamily, member 5; B-cell surface antigen CD40; OTTHUMP00000031699; OTTHUMP 00000031700
Gene ID: 958
mRNA Refseq: NM_001250
Protein Refseq: NP_001241
MIM: 109535
UniProt ID: P25942
Chromosome Location: 20q12-q13.2
Pathway: Adaptive Immunity Signaling; Allograft rejection; Asthma; Autoimmune thyroid disease; CD40/CD40L signaling; Cell adhesion molecules (CAMs); Cytokine-cytokine receptor interaction; HTLV-I infection; IL-6 Signaling Pathway; Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Inflammatory Response Pathway; Intestinal immune network for IgA production; Malaria; NLR proteins; Primary immunodeficiency
Function: enzyme binding; receptor activity; protein binding; signal transducer activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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