Recombinant Human Collagen, Type XVIII, Alpha 1

• Cat.No.: COL18A1-4986H
• Product Overview: Recombinant human COL18A1 was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: COL18A1-4986H
• Description: Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF basic.
• Source: Human
• Host: E.coli
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of Endostatin protein corresponding to amino acids MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM
• Molecular Mass: 20.2 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: COL18A1 collagen, type XVIII, alpha 1 [ Homo sapiens ]
• Official Symbol: COL18A1
• Synonyms: COL18A1; collagen, type XVIII, alpha 1; KNO; KNO1; FLJ27325; FLJ34914; MGC74745; collagen alpha-1(XVIII) chain; endostatin; antiangiogenic agent; multi-functional protein MFP
• Gene ID: 80781
• mRNA Refseq: NM_030582
• Protein Refseq: NP_085059
• MIM: 120328
• UniProt ID: P39060
• Chromosome Location: 21q22.3
• Pathway: Direct p53 effector; FOXA1 transcription factor network; Protein digestion and absorption
• Function: extracellular matrix structural constituent; metal ion binding; protein binding