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Recombinant Human DNA-Damage-Inducible Transcript 3, His-tagged

Cat.No. : DDIT3-4948H
Product Overview : Recombinant GADD153 fused with His-tag, was expressed in E. coli and purified by conventional chromatography techniques.
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Cat. No. : DDIT3-4948H
Description : GADD153, also known as DNA-damage-inducible transcript 3 (DDIT3), is a basic domain-leucine zipper(bZIP) transcription factor of C/EBP family. This protein has been shown to be up-regulated by several stresses, such as amino acid or glucose starvation, endoplasmic reticulum (ER) stress, osmotic stress and hypoxia. GADD153 protein may play a role in ER stress-mediated apoptosis and in disease including diabetes, brain ischemia and neurodegenerative disease.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 50mM NaCl and 10% glycerol.
Purity : > 90 by SDS - PAGE
Sequence : 1-169 amino acids: MGSSHHHHHH SSGLVPRGSH MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA
Molecular Mass : 21.3 kDa (189aa), confirmed by MALDI-TOF.
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : DDIT3 DNA-damage-inducible transcript 3 [ Homo sapiens ]
Official Symbol : DDIT3
Synonyms : DDIT3; DNA-damage-inducible transcript 3; CHOP; CEBPZ; CHOP10; GADD153; MGC4154; C/EBP zeta; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153; C/EBP-homologous protein; C/EBP homologous protein; CCAAT/enhancer-binding protein homologous protein; growth arrest- and DNA damage-inducible
Gene ID : 1649
mRNA Refseq : NM_004083
Protein Refseq : NP_004074
MIM : 126337
UniProt ID : P35638
Chromosome Location : 12q13.1-q13.2
Pathway : MAPK signaling pathway; Diabetes pathways
Function : protein dimerization activity; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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