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Recombinant Human ADP-Ribosylation Factor-Like 4A, His-tagged

Cat.No. : ARL4A-4972H
Product Overview : Recombinant human ARL4A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
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Cat. No. : ARL4A-4972H
Description : ARL4A, also known as ADP-ribosylation factor-like protein 4A, is a member of the ARF-like protein (ARL) subfamily of small GTPases. It is most closely related to ARL6 and ARL7. Unlike ARFs, ARL4 does not activate the cholera toxin ADP-ribosyltranferase. This protein may play a role in neurogenesis during embryonic development and somitogenesis in the early stages of adult spermatogenesis.
Concentration : 0.5 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.
Purity : > 90% by SDS - PAGE
Sequence : 1-200 amino acids: MGSSHHHHHH SSGLVPRGSH MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQ
Molecular Mass : 24.7 kDa (220aa), confirmed by MALDI-TOF
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : ARL4A ADP-ribosylation factor-like 4A [ Homo sapiens ]
Official Symbol : ARL4A
Synonyms : ARL4A; ADP-ribosylation factor-like protein 4A; OTTHUMP00000155200; OTTHUMP00000201576; OTTHUMP00000201577; ADP-ribosylation factor-like 4
Gene ID : 10124
mRNA Refseq : NM_001037164
Protein Refseq : NP_001032241
MIM : 604786
UniProt ID : P40617
Chromosome Location : 7p21.3
Function : GTP binding; nucleotide binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there any known disease associations or mutations in the ARL4A gene? 08/02/2022

Mutations in the ARL4A gene have not been extensively studied. However, some studies have suggested its potential involvement in cancer progression and metastasis. Further research is required to fully understand any disease associations or potential therapeutic implications.

Can dysregulation of ARL4A expression lead to any cellular defects? 06/28/2022

Dysregulation of ARL4A expression has been implicated in various pathological conditions. Alterations in its expression levels or activity may contribute to abnormalities in vesicular trafficking, cytoskeletal organization, and overall cellular homeostasis.

Does ARL4A interact with other proteins? 06/17/2022

Yes, ARL4A interacts with several proteins to regulate various cellular processes. It can interact with GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs), and effector proteins involved in vesicle trafficking and cytoskeletal dynamics.

Is ARL4A involved in any signaling pathways? 07/18/2018

ARL4A itself is not considered a signaling molecule in canonical signaling pathways. However, it may modulate the activity of certain signaling molecules by regulating their intracellular transport or localization.

In which tissues or cell types is ARL4A expressed? 04/07/2018

ARL4A is generally expressed in a wide range of tissues and cell types, indicating its ubiquitous nature. Its expression may vary in different tissues and developmental stages.

Can the ARL4A protein be targeted for therapeutic purposes? 08/22/2016

The therapeutic potential of targeting ARL4A is currently being explored. Its involvement in cellular processes and potential role in diseases make it a potential therapeutic target. However, further research is needed to fully understand its mechanisms and implications for targeted therapeutics.

Customer Reviews (8)

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Reviews
11/13/2022

    The versatility of the ARL4A protein makes it a valuable asset in my research.

    11/05/2022

      The ARL4A protein is renowned for its exceptional quality, making it a perfect match for my experimental requirements.

      03/25/2019

        the ARL4A protein exhibits superior performance across a range of experimental applications.

        09/30/2018

          In addition to its high-quality attributes, the manufacturer of the ARL4A protein offers exemplary technical support.

          06/14/2017

            Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.

            06/10/2017

              Whether I am studying protein interactions, cellular localization, or signaling pathways, the ARL4A protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.

              01/26/2016

                Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

                01/16/2016

                  Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.

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